Results 121 to 130 of about 729,834 (302)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The texture analysis of computed tomography studies in clear cell renal cell carcinoma: reproducibility of 2D and 3D segmentation

Alʹmanah Kliničeskoj Mediciny
Background: Differentiation of tumor grade at the preoperative stage is of utmost importance for the modification of the treatment strategy and the extent of operation.
Stanislava V. Khromova, Grigory G. Karmazanovsky, Natalia A. Karelskaya, Ivan S. Gruzdev   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Segment AnyNeuron

2025 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)
Image segmentation plays an integral part in neuroimage analysis and is crucial for understanding brain disorders. Deep Learning (DL) models have shown exponential success in computer vision tasks over the years, including image segmentation. However, to achieve optimal performance, DL models require extensive annotated data for training, which is ...
Taha Razzaq, Ahmed Qazi, Asim Iqbal
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Texture measures for segmentation [PDF]

, 2007
Includes bibliographical references (p. 67-72).Texture is an important visual cue in both human and computer vision. Segmenting images into regions of constant texture is used in many applications.
Haddad, Stephen
core   +1 more source

Enhanced Circuit Board Analysis: Infrared Image Segmentation Utilizing Markov Random Field (MRF) and Level Set Techniques

Engineering Reports
Circuit board analysis plays a critical role in ensuring the reliability of electronic devices by identifying temperature distribution, assessing component health, and detecting potential defects.
T. Praveenkumar, S. Anthoniraj, S. Kumarganesh, M. Somaskandan, K. Martin Sagayam, Binay Kumar Pandey, Digvijay Pandey, Suresh Kumar Sahani   +7 more
doaj   +1 more source

U-Net Convolutional Neural Network for Mapping Natural Vegetation and Forest Types from Landsat Imagery in Southeastern Australia

Journal of Imaging
Accurate and comparable annual mapping is critical to understanding changing vegetation distribution and informing land use planning and management. A U-Net convolutional neural network (CNN) model was used to map natural vegetation and forest types ...
Tony Boston, Albert Van Dijk, Richard Thackway   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source