Results 141 to 150 of about 590,345 (318)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Blinded, bias-controlled multi-rater evaluation of human-versus-AI brain metastasis segmentation using a hybrid foundation-model framework. [PDF]

Med Phys
Han Y, Zhu E, Mekdash MHA, Awad O, Pathak P, Liang S, Hamstra DA, Zhang X, Siddiqui ZA, Sun B.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Two-Stage Dynamic Synergistic Segmentation Method for Myocardial Pathology. [PDF]

J Imaging
Ruan D, Zhang X, Yuan Z, Lu Z, Xia L, Jiang M.   +5 more
europepmc   +1 more source

Zero-shot segmentation of spinal vertebrae with metastatic lesions: an analysis of Meta’s Segment Anything Model 2 and factors affecting learning free segmentation

Rushmin Khazanchi, Sachin Govind, Rishi Jain, Rebecca Du, Nader S. Dahdaleh, Christopher S. Ahuja, Najib E. El Tecle   +6 more
openalex   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Brain Tumor Segmentation Using U-Net With ResNet50 Encoder for Enhanced MRI Analysis. [PDF]

Int J Biomed Imaging
Alkahtani AM, Dardouri S.
europepmc   +1 more source

High-Resolution Encoder-Decoder Networks for Low-Contrast Medical Image Segmentation

Jun Lian, Dinggang Shen, Dong Nie, Sihang Zhou, Jianping Yin, Ehsan Adeli   +5 more
openalex   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

SiNuS: A comprehensive dataset for singular nuclei segmentation for <i>HER2</i> grading of breast cancer. [PDF]

Data Brief
Hossain MS, Rahman MS, Ahmed M.
europepmc   +1 more source