FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
TotalSegmentator-AI for aortic segmentation in CT: Reliable performance in normal anatomy but limited utility in pathological aortic disease. [PDF]
Eur J Radiol OpenEl Rahal D +4 more
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
A Fully Automated Pipeline for Vertebral Structural Assessment From Medical Images. Application Under Metastatic Conditions. [PDF]
Int J Numer Method Biomed EngGandia-Vañó B +4 more
europepmc +1 more source
Hybrid improved fuzzy C-means and watershed segmentation to classify Alzheimer’s using deep learning
Esraa H. Ali +2 more
openalex +2 more sources
A MapX-based Segmentation Algorithm of Region Feature by Polyline
, 2013 Dasheng Wu
openalex +2 more sources
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
YoLeTooth: A Unified Framework for Joint Tooth Segmentation and Periapical Lesion Detection in Panoramic Radiographs. [PDF]
J ImagingScarano G +3 more
europepmc +1 more source
Guided Medical Data Segmentation Using Structure-Aligned Planar Contours
, 2016 Michelle Holloway
openalex +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source