Results 41 to 50 of about 39,077 (276)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Integrated Wavefront Detection for Large-Aperture Segmented Planar Mirrors: Concept & Principle
PhotonicsPlanar mirrors play a crucial role in autocollimation testing and optical beam relay systems of telescopes and other fields. However, for the next-generation large-aperture telescopes, typical monolithic planar mirrors fall short in meeting anticipated ...
Rui Sun, Qichang An, Xiaoxia Wu
doaj +1 more source
On-sky multi-wavelength phasing of segmented telescopes with the Zernike phase contrast sensor
, 2011 Future Extremely Large Telescopes will adopt segmented primary mirrors with several hundreds of segments. Cophasing of the segments together is essential to reach high wavefront quality.
Cavarroc +20 more
core +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Hierarchical Bidirectional GRU Model With Attention for EEG-Based Emotion Classification
IEEE Access, 2019 In this paper, we propose a hierarchical bidirectional Gated Recurrent Unit (GRU) network with attention for human emotion classification from continues electroencephalogram (EEG) signals.
J. X. Chen, D. M. Jiang, Y. N. Zhang
doaj +1 more source
Large-scale solar thermal collector concepts [PDF]
, 1975 Thermal collector could be used ultimately to power steamplant to produce electricity. Collector would consist of two major subsystems: (1) series of segmented tracking mirrors with two axes of rotation and (2) absorber mounted on centrally located ...
Brantley, L. W., Jr.
core +1 more source
, 2015 We have developed a non-sequential ray-tracing simulation library, ROOT-based simulator for ray tracing (ROBAST), which is aimed to be widely used in optical simulations of cosmic-ray (CR) and gamma-ray telescopes.
Noda, Koji +2 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Segmented coronagraph design and analysis (SCDA): an initial design study of apodized vortex coronagraphs [PDF]
, 2017 The segmented coronagraph design and analysis (SCDA) study is a coordinated effort, led by Stuart Shaklan (JPL) and supported by NASA's Exoplanet Exploration Program (ExEP), to provide efficient coronagraph design concepts for exoplanet imaging with ...
Jewell, Jeffrey +4 more
core +1 more source