Results 41 to 50 of about 7,316 (282)

Zernike phase sensor for phasing of segmented telescopes [PDF]

, 2007
We study an adaptive dynamical feedback system for phasing of segmented mirrors. The system, which combines a Zernike wave front sensor with a feedback loop, is shown to be capable of separating (static) misalignment errors of segmented mirrors from ...
Huang, T., Lu, W., Zhang, S., Greenaway, A. H.   +3 more
core   +1 more source

Integrated Wavefront Detection for Large-Aperture Segmented Planar Mirrors: Concept & Principle

Photonics
Planar mirrors play a crucial role in autocollimation testing and optical beam relay systems of telescopes and other fields. However, for the next-generation large-aperture telescopes, typical monolithic planar mirrors fall short in meeting anticipated ...
Rui Sun, Qichang An, Xiaoxia Wu
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Hierarchical Bidirectional GRU Model With Attention for EEG-Based Emotion Classification

IEEE Access, 2019
In this paper, we propose a hierarchical bidirectional Gated Recurrent Unit (GRU) network with attention for human emotion classification from continues electroencephalogram (EEG) signals.
J. X. Chen, D. M. Jiang, Y. N. Zhang
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A new piston control strategy for segmented mirrors [PDF]

, 1994
One approach to the adaptive control of large segmented mirrors involves sending tilt commands to each segment and allowing each segment to minimize the distance between its edges and those of (all or some of) its neighbors.
Olivier, Philip D.
core   +1 more source

Imaging with Hexagonal Segmented Mirror

Engineering and Technology Journal, 2012
Different hexagons configuration aperture models of the optical telescope mirror is carefully considered in this study. The point spread function and the modulation transfer function of a reference star using different hexagons configuration are computed and the quantitative assessment for the results are described. It has been shown that the height of
Fouad N. Hassan, A.T. Mohammed, A. J. Tawfiq   +2 more
openaire   +2 more sources