Results 61 to 70 of about 414,718 (315)

An extrinsic motor directs chromatin loop formation by cohesin

The EMBO Journal
The ring-shaped cohesin complex topologically entraps two DNA molecules to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide-ranging implications for gene regulation, and cohesin is thought to achieve ...
Thomas M Guérin, Christopher Barrington, Georgii Pobegalov, Maxim I Molodtsov, Frank Uhlmann   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Workplace Segregation in the United States: Race, Ethnicity, and Skill [PDF]

We study workplace segregation in the United States using a unique matched employer-employee data set that we have created. We present measures of workplace segregation by education and language, and by race and ethnicity, and ­ since skill is often ...
David Neumark, Judith Hellerstein
core   +2 more sources

Dynamic blebbing and absence of organelle transfer during mouse oocyte formation

The EMBO Journal
Oocyte formation in mammals is a tightly regulated process essential for female fertility, yet the underlying mechanisms remain poorly understood. In this study, we establish an ex vivo culture system that faithfully recapitulates in vivo development and
Eishi Aizawa, So Shimamoto, Eriko Kajikawa, Junko Hara, Takaya Abe, Hiroki Shibuya, Tomoya S Kitajima   +6 more
doaj   +1 more source

Description of the Seminiferous Epithelium Cycle Stages in the Zebra Finch Taeniopygia guttata

Animals
Spermatogenesis in passerine birds remains poorly characterized. Previous studies focused on the steps of spermiogenesis, while a detailed staging of the seminiferous epithelium cycle is still lacking for this order.
Tatiana Bikchurina, Daria Rubtsova, Daria Odnoprienko, Pavel Borodin, Anna Torgasheva, Lyubov Malinovskaya   +5 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Le vote intermittent - Comment les ségrégations urbaines influencent-elles les comportements électoraux en Ile-de-France ?

L'Espace Politique, 2014
This paper studies the influence of social inequalities on turnout fluctuations in the region Ile-de-France between 2002 and 2012. It uses aggregate electoral and census data at the municipality scale.
Antoine Jardin
doaj   +1 more source

“The idea of beautifying the surroundings”: Bloemfontein’s (Mangaung) Batho location a “garden location”? (ca. 1918-1939)

Contree, 2020
In 1918, the Municipality of Bloemfontein saw the establishment of Batho as the new location for the town’s black and coloured people as an opportunity to not only establish a so called model location but also a garden location.
Derek du Bruyn, Marietjie Oelofse
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source