Results 41 to 50 of about 66,992 (298)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Confins, 2019 Urban spatial segregation in developing countries is related to the social and economic differences of its population. This study presents an index of urban spatial segregation based on socioenvironmental and demographic data and performs statistical ...
Marcos Roberto Martines +4 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Residential segregation of socioeconomic variables and health indices in Iran
International Journal of Preventive Medicine, 2013 Background: Measures of segregation are essential tools for evaluation of social equality. They describe complex structural patterns by single quantities and allow the comparison of inequalities over time or between residential places. In many countries,
Seyed Saeed Hashemi Nazari +2 more
doaj
Labour segregation in the spanish regions from 1996 to 2010 [PDF]
Investigaciones Regionales - Journal of Regional Research, 2013 This paper analyzes the evolution of gender segregation in Spanish labour market between 1996 and 2010, with particular emphasis on the different trends Spanish regions.
Diego Dueñas Fernández +2 more
doaj
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Numerical Investigation on the Electroslag Remelting of High Carbon Martensitic Stainless Steels
Metals, 2023 Control of solidification structure and segregation is crucial to improve the service performance of high carbon martensitic stainless steels. Design of the electroslag remelting (ESR) process based on the essential parameters of melting rate, filling ...
Xingyu Liu +4 more
doaj +1 more source
Occupational gender segregation: Index measureiient and econometric modeling [PDF]
Demography, 1998 Abstract Empirical studies of gender segregation by occupation must be founded on rigorous measurement procedures. There appears to be a consensus that any index used in the analysis of time-series or international cross-section employment data must be either margin-free or decomposable to yield a margin-free component. On the other hand,
openaire +2 more sources
mutualinf: An R Package for Computing and Decomposing the Mutual Information Index of Segregation
The R Journal, 2023 In this article, we present the R package mutualinf for computing and decomposing the mutual information index of segregation by means of recursion and parallelization techniques. The mutual information index is the only multigroup index of segregation that satisfies strong decompos- ability properties, both for organizational units and groups.
Rafael Fuentealba-Chaura +3 more
openaire +4 more sources