Results 91 to 100 of about 1,591,675 (322)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Does ECT permanently alter seizure threshold?

Biological Psychiatry, 1993
Recent research has raised the possibility that electroconvulsive therapy (ECT) results in a persistent elevation of seizure threshold among males. In this study, seizure threshold, quantified by the method of limits procedure, was assessed at the first and last treatments of 148 consecutive depressed patients. Patients with and without a prior history
R B, Krueger, J M, Fama, D P, Devanand, J, Prudic, H A, Sackeim   +4 more
openaire   +2 more sources

Endogenous Neuropeptide Y Prevents Recurrence of Experimental Febrile Seizures by Increasing Seizure Threshold [PDF]

Journal of Molecular Neuroscience, 2005
Febrile seizures (FSs) typically occur at the onset of fever and do not recur within the same febrile episode despite enduring or increased hyperthermia. Recurrent seizures during the same febrile episode are considered "complex," with potentially altered prognosis.
Dubé, Céline, Brunson, Kristen L, Eghbal-Ahmadi, Mariam, Gonzalez-Vega, Rebeca, Baram, Tallie Z   +4 more
openaire   +4 more sources

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

PLoS ONE, 2014
Objective Eclampsia is a poorly understood but potentially fatal complication of pregnancy. Research to date on this disorder has been hampered by the lack of a suitable animal model.
Qian Huang, Lei Liu, Bihui Hu, X. Di, S. Brennecke, Huishu Liu   +5 more
semanticscholar   +1 more source

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography [PDF]

, 2009
Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit driving, even if a patient is free of seizures.
A. W. McEvoy, Alexander, Babb, Basser, Bassi, Behrens, Chen, Ciccarelli, Cook, Curcio, D. C. Alexander, Duncan, Ebeling, Egan, FALCONER, Fris  n, G. J. M. Parker, HARVEY, Hughes, J. Acheson, J. S. Duncan, Kamada, Kier, Kirkham, Krolak-Salmon, M. Cercignani, M. J. Koepp, M. R. Symms, M. Yogarajah, Manji, Marino, Mori, N. K. Focke, Nilsson, Nilsson, Oldfield, Parker, Penfield, Powell, Ray, S. Bonelli, Semah, Spalding, Tecoma, Wiebe, Woermann, Yamada, Yamamoto, Yasargil   +48 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Variables associated with clinical outcomes and switching from unilateral to bitemporal electroconvulsive therapy: a retrospective study

Frontiers in Psychiatry
BackgroundElectroconvulsive therapy (ECT) remains the most effective treatment for many patients with severe and/or resistant psychiatric disorders. Right unilateral (RUL) ECT, particularly when administered with titration and ultrabrief pulses, provides
Erika Sordo, Louise Fuet, Federica Porpiglia, Marwa Zrelli, Mickaël Amagat, Pierre De Maricourt, Raphaël Gaillard, Raphaël Gaillard, Sarah Smadja, Fabien Vinckier, Fabien Vinckier, Caroline Schimpf, Françoise Tomberli, Aurélien Mazeraud, Aurélien Mazeraud, Philippe Domenech, Philippe Domenech, Philippe Domenech, Moussa A. Chalah, Moussa A. Chalah   +19 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Integrating Artificial Intelligence with Real-time Intracranial EEG Monitoring to Automate Interictal Identification of Seizure Onset Zones in Focal Epilepsy

, 2018
An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy.
Berry, Brent, Brinkmann, Benjamin, Cimbalnik, Jan, Iyer, Ravishankar, Kremen, Vaclav, Stead, Matt, Van Gompel, Jamie, Varatharajah, Yogatheesan, Worrell, Gregory   +8 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source