Results 111 to 120 of about 1,591,675 (322)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Successful switch from bilateral brief pulse to right unilateral ultrabrief pulse electroconvulsive therapy after failure to induce seizures

Neuropsychiatric Disease and Treatment, 2018
Hirotsugu Kawashima,1 Yuko Kobayashi,1 Taro Suwa,2 Toshiya Murai,2 Ryuichi Yoshioka1 1Department of Psychiatry, Toyooka Hospital, Toyooka, Hyogo, Japan; 2Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan ...
Kawashima H, Kobayashi Y, Suwa T, Murai T, Yoshioka R   +4 more
doaj  

Association of oxcarbazepine concentration with seizure frequency in pregnant women with epilepsy

Epilepsy & Behavior Reports
The management of epilepsy during pregnancy presents particular challenges for neurologists worldwide. Currently, there are no clear recommendations for oxcarbazepine (OXC) specific target concentration during pregnancy.
Lin-yan Wei, Zheng-yan-ran Xu, Zhen-zhen Lai, Na Dong, Yi-wen Sang, Yi Guo   +5 more
doaj   +1 more source

Electro-shock Seizure Threshold of Metacorticoid Hypertensive Rats [PDF]

Nature, 1960
IT has been shown1–5 that chronic administration of deoxycorticosterone acetate decreases brain excitability and potentiates anticonvulsant drugs, and that this effect is correlated with increased plasma and decreased brain intracellular sodium concentrations. In contrast, adrenal insufficiency produces the opposite effects2.
openaire   +2 more sources

Can brains generate random numbers?

, 2012
Motivated by EEG recordings of normal brain activity, we construct arbitrarily large McCulloch-Pitts neural networks that, without any external input, make every subset of their neurons fire in some iteration (and therefore in infinitely many iterations)
Chvátal, Vašek, Goldsmith, Mark
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Elongation of pulse width as an augmentation strategy in electroconvulsive therapy

Neuropsychiatric Disease and Treatment, 2014
Hirotsugu Kawashima,1 Taro Suwa,2 Toshiya Murai,2 Ryuichi Yoshioka1 1Department of Psychiatry, Toyooka Hospital, Hyogo, Japan; 2Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan Abstract: Inducing adequate ...
Kawashima H, Suwa T, Murai T, Yoshioka R
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Anticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice

Basic and Clinical Neuroscience, 2020
Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in two in vivo seizure models. Methods: Seizures were induced in male adult Swiss mice
Tajmah Mombeini, Babak Asadpour Behzadi, Ramtin Ejtemaei, Freidoun Tahmasbi, Mohammad Kamalinejad, Ahmad Reza Dehpour   +5 more
doaj  

The effect of chronic caffeine intake on pentylenetetrazole (PTZ)-induced seizure threshold and nitric oxide metabolites in mice [PDF]

, 2018
Background: Long-term caffeine intake decreases seizure susceptibility and has protective effect. This protective effect of caffeine may be due to the blockade of A2A adenosine receptors.
Esmaili, Zahra, Heydari, Azhdar
core