Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex. [PDF]
Sci Rep, 2019 Abnormal synaptic plasticity has been implicated in several neurological disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD). Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that manifests with seizures ...
Basu T +7 more
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Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice. [PDF]
Neurotox Res, 2018 Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the
Socała K +6 more
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The cardiovascular safety of the empirical measurement of the seizure threshold in electroconvulsive therapy. [PDF]
BJPsych Bull, 2015 Aims and method The Royal College of Psychiatrists' Committee on Electroconvulsive Therapy (ECT) and Related Treatments advises the measurement of initial seizure threshold in all patients undergoing ECT if possible.
Mizen L, Morton C, Scott A.
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Conditional Disabled-1 Deletion in Mice Alters Hippocampal Neurogenesis and Reduces Seizure Threshold. [PDF]
Front Neurosci, 2016 Many animal models of temporal lobe epilepsy (TLE) exhibit altered neurogenesis arising from progenitors within the dentate gyrus subgranular zone (SGZ).
Korn MJ, Mandle QJ, Parent JM.
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BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice
Frontiers in Systems Neuroscience, 2014 The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with diurnal rhythms.
Jason Robert Gerstner +10 more
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Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice ...
Ebrahim Kouchaki +2 more
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Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats. [PDF]
Epilepsia, 2018 Dhir A, Rogawski MA.
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Should We Re-estimate the Seizure Threshold during Maintenance ECT? [PDF]
Indian Journal of Psychological Medicine, 2023 Abhiram Narasimhan Purohith +2 more
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The role of GABAergic receptors in acute, subacute, and withdrawal syndrome on pain and seizure thresholds in mice: A connection to mitochondrial function and oxidative stress in the brain [PDF]
Toxicology ReportsOne of the most serious neurological disorders is epilepsy. This study aimed to investigate the effects of baclofen, a GABA receptor agonist, on pain and seizure thresholds, as well as on oxidative damage in brain mitochondrial membranes of mice.
Roghayeh Jahani +4 more
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Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and in vivo experiment [PDF]
Frontiers in NeurologyObjectiveTo evaluate the causality between interleukins (ILs) and epilepsy using Mendelian randomization (MR) analysis. Furthermore, in vivo experiments were conducted to validate the results.MethodsAll summary datasets for MR analysis were sourced from ...
Yunyun Lu +9 more
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