Results 211 to 220 of about 2,212,868 (299)

Variations and evolution of HIV-1 provirus in peripheral blood under the pressure of ART. [PDF]

Virus Evol
Liang Y, Deng H, Li Q, Zhang C, Li J, Kong Q, Zou Z, Li L, Chen W.   +8 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Randomization across breeding cohorts improves the accuracy of conventional and genomic selection. [PDF]

Plant Genome
Ackerman A, Rutkoski J.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A breeding strategy for high-oleic acid content and high-yield peanut using Tag SNPs and genomic selection. [PDF]

BMC Plant Biol
Guo M, Miao J, Li Y, Yin J, Wang P, Luo F, Li S, Hu J, Liu W, Zhang T, Ren L, Deng L.   +11 more
europepmc   +1 more source

Genetic traces of selection [PDF]

Nature, 2013
openaire   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Whole-genome resequencing identifies adaptive variation associated with complex terrain in southwestern Chinese ducks. [PDF]

Poult Sci
Li Q, Liu H, Li L, Huang A, Hu J, Bai L, Han C.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Wanted: A population genetic theory of biological noise regulation. [PDF]

PLoS Genet
Weinreich DM, Sgouros T, Raynes Y, Burtsev H, Chang E, Rajakumar S, Bravo IG, Petak C.   +7 more
europepmc   +1 more source