Results 91 to 100 of about 10,138,963 (347)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
SELECTION DIFFERENTIALS AND SELECTION COEFFICIENTS [PDF]
Genetics, 1978 ABSTRACT Proof is offered that s ≃ ig for all forms of selection where fitness is a nondecreasing function of a normally distributed phenotype (called fitness potential); s is selection coefficient, i is standard selection differential, and g is standard differential effect of a locus genotype.
openaire +3 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Bayesian Robust Inference of Sample Selection Using Selection-t Models
, 2014 Heckman selection model is the most popular econometric model in analysis of data with sample selection. However, selection models with Normal errors cannot accommodate heavy tails in the error distribution.
Ding, Peng
core +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Current Biology, 2010 Abstract ‘Levels of selection’ examines the levels-of-selection question, which asks whether natural selection acts on individuals, genes, or groups. This question is one of the most fundamental in evolutionary biology, and the subject of much controversy. Traditionally, biologists have mostly been concerned with selection and adaptation
openaire +3 more sources
Selection, Stability and Renormalization
, 1993 We illustrate how to extend the concept of structural stability through applying it to the front propagation speed selection problem. This consideration leads us to a renormalization group study of the problem.
Andronov +58 more
core +1 more source