Results 111 to 120 of about 10,390,535 (299)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Kuangchan zonghe liyongThis is an article in the field of metallurgical engineering. A beneficiation and smelting plant processes two kinds of gold ores: primary ore and oxidized ore. The primary ore is treated by conventional flotation process.
Yanbo CHEN +3 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Protein and starch content in winter wheat grain at different stages of growth and maturation
Зерновое хозяйство РоссииThe current study was conducted in 2018, 2019 and 2021, on the experimental plots of the Volga Region RIBSP. The object of the study was the winter common wheat variety ‘Povolzhskaya Niva’.
I. I. Sharapov +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Flotation of an Arsenic Bearing High Sulfur Gold Mine in Gansu Province
Kuangchan zonghe liyongThis is an article in the field of mineral processing engineering. The gold mineral in an arsenic bearing high sulfur gold mine has a close symbiotic relationship with pyrite and arsenopyrite, and the recovery rate of concentrate gold is not ideal in the
Yanbo CHEN +3 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Genome-wide association studies on leaf midrib architecture in maize
Frontiers in Plant ScienceIntroductionLeaf midrib architecture (LMA) in maize plays essential roles in supporting leaf structure and facilitating photosynthetic performance. Despite its importance for plant architecture and yield potential, the genetic basis underlying key midrib
Dongdong Dang +8 more
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