Results 171 to 180 of about 10,138,963 (347)

How was Wallace led to the Discovery of Natural Selection? [PDF]

, 1895
A.B. Meyer
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. [PDF]

Evol Anthropol
Kasser SM, Lala KN, Fortunato L, Feldman MW.   +3 more
europepmc   +1 more source

The origin of species by means of natural selection; or, the preservation of favored races in the struggle for life, by Charles Darwin ... with additions and corrections from 6th and last English ed ...

, 1915
Charles Darwin
openalex   +2 more sources

Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds [PDF]

, 1914
Emilia Schax, Janek Neunaber, Frank Stahl, Johanna‐Gabriela Walter, Thomas Scheper, Simone Eichner, Andreas Kirschning, Carsten Zeilinger   +7 more
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

A novel expectation-maximization approach to infer general diploid selection from time-series genetic data. [PDF]

PLoS Genet
Fine AG, Steinrücken M.
europepmc   +1 more source

Mathematical contributions to the theory of evolution. IV. On the probable errors of frequency constants and on the influence of random selection on variation and correlation

, 1898
Karl Pearson, L. N. G. Filon
openalex   +1 more source

Selection in Cladocera on the basis of a physiological character [PDF]

, 1922
Arthur Mangun Banta
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source