Results 81 to 90 of about 1,049,088 (304)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

An Empirical Analysis of the Effects of Selectivity and Endogeneity Problems on Returns to Education [PDF]

open access: yesفصلنامه پژوهش‌های اقتصادی ایران, 2008
This articles aims at evaluating the effects of selectivity and endogeneity problems on returns to education caused by individuals' decision to attend school and to participate in the labour market.
Abolghasem Naderi
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Tumor size and postoperative kidney function following radical nephrectomy

open access: yesClinical Epidemiology, 2019
Robert J Ellis,1–4 Victoria M White,5,6 Damien M Bolton,7,8 Michael D Coory,8 Ian D Davis,9,10 Ross S Francis,2–4 Graham G Giles,5,8 Glenda C Gobe,3,4 Rachel E Neale,1 Simon T Wood,3–4,10 Susan J Jordan1,31Department of Population ...
Ellis RJ   +10 more
doaj  

Shift work and cardiovascular disease – do the new studies add to our knowledge?

open access: yesScandinavian Journal of Work, Environment & Health, 2018
The association of shift work with cardiovascular disease (CVD) has been studied for decades with new systematic reviews repeatedly being published (1–4). Based on 34 studies and over 2 million employees, the systematic review of Vyas et al (4) concluded
Mikko Härmä   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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