Results 91 to 100 of about 1,150,534 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Accounting for Label Shift of Positive Unlabeled Data under Selection Bias
International Journal of Applied Mathematics and Computer ScienceWe consider the scenario when two samples of positive unlabeled (PU) data are available and for the second sample the change in prior probability of classes occurs while distributions of predictors in classes remain the same (label shift setting).
Mielniczuk Jan, Wawrzeńczyk Adam
doaj +1 more source
Overvalidation in Machine Learning: Empirical Evidence and Theoretical Insights
IEEE AccessOver the past decades, advances in Machine Learning have greatly increased both the variety and the complexity of available algorithms. As a result, solving specific tasks often requires making numerous decisions, such as selecting the most suitable ...
Fabrizio Mori +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Gender pay gaps in Morocco: urban-rural disparities across the wage distribution
Development Studies ResearchGender pay gaps persist as a significant feature of labor markets in developing countries, with disparities varying across the wage distribution and between urban and rural areas.
Fatima Mounir +2 more
doaj +1 more source