Results 81 to 90 of about 1,150,534 (306)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Pseudo-Panel Decomposition of the Blinder–Oaxaca Gender Wage Gap

open access: yesEconometrics
This article introduces a novel approach to decomposing the Blinder–Oaxaca gender wage gap using pseudo-panel data. In many developing countries, panel data are not available; however, understanding the evolution of the gender wage gap over time requires
Jhon James Mora, Diana Yaneth Herrera
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Relative age effects in Rugby union and Rugby league: a systematic review and meta-analysis

open access: yesFrontiers in Sports and Active Living
IntroductionRelative Age Effects (RAEs) are prominent factors affecting youth sport participation and talent identification and selection processes. In rugby, RAEs appear to be prevalent in both Rugby League (RL) and Rugby Union (RU), yet no study has ...
P. R. Brustio   +11 more
doaj   +1 more source

A Promising New Approach to Eliminating Selection Bias [PDF]

open access: bronze, 2009
Laura R. Peck   +2 more
openalex   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating and quantifying selection bias in research using placental pathology samples

open access: yesPregnancy
Introduction Increasing research interest has focused on placental pathology and pregnancy outcomes. Placental pathology examinations that are requested by the delivering provider are often used for research due to convenience, potentially introducing ...
Renee Odom‐Konja   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy