Results 81 to 90 of about 4,222,943 (302)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Selection bias in innovation studies: a simple test. [PDF]

open access: yes
The study of the innovative output of firms often relies on a count of patents filed at one single office of reference such as the European Patent Office (EPO).
Wastyn, Annelies, de Rassenfosse, G.
core  

Self-Selection Bias in Randomized and Observational Studies on Screening Mammography: A Quantitative Assessment. [PDF]

open access: yesClin Epidemiol
Philippe Autier International Prevention Research Institute (IPRI), Lyon, 69002, FranceCorrespondence: Philippe Autier, International Prevention Research Institute (iPRI), Lyon, 69002, France, Email Philippe.autier@i-pri.orgBackground: Observational ...
Autier P.
europepmc   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission

open access: yes, 2011
Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 11/10/11Official website of the Connecticut Judicial Selection Commission.

core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Measurement equivalence in mixed mode surveys

open access: yesFrontiers in Psychology, 2015
Surveys increasingly use mixed mode data collection (e.g., combining face-to-face and web) because this controls costs and helps to maintain good response rates.
Joop J. Hox   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Understanding Neighbourhood Effects: Selection Bias and Residential Mobility [PDF]

open access: yes
The number of studies investigating neighbourhood effects has increased rapidly over the last two decades. Although many of these studies claim to have found evidence for neighbourhood effects, most 'evidence' is likely the result of reversed causality ...
Bergström, Lina, van Ham, Maarten
core  

Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission

open access: yes, 2017
Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 5/8/17Official website of the Connecticut Judicial Selection Commission ...

core   +1 more source

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