Results 181 to 190 of about 507,819 (307)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The genomic consequences of sexual selection

, 2012
Sex-differences in phenotype, development, and life-history can alter the strength of selection experienced by males and females. In particular, theoretical models have demonstrated that differences in the strength of selection between the sexes can influence the deleterious mutation load of populations.
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Biological Consequences of Declining Human Fertility. [PDF]

Public Health Chall
Henneberg M, Rühli F.
europepmc   +1 more source

Selection for temperament has no negative consequences on important production traits in farmed mink1 [PDF]

, 2019
Janne Pia Thirstrup, Trine Michelle Villumsen, Jens Malmkvist, Mogens Sandø Lund   +3 more
openalex   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

How can the use of different modes of survey data collection introduce bias? An introduction to mode effects using directed acyclic graphs (DAGs). [PDF]

Am J Epidemiol
Tomova GD, Silverwood RJ, Tennant PWG, Wright L.   +3 more
europepmc   +1 more source

Causation versus selection: A genetically informed study of Marital instability and its consequences for young-adult offspring

, 2005
Brian M. D’Onofrio
openalex   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The cost of cure: cancer therapies sculpt somatic evolution and signaling landscapes in normal tissues. [PDF]

Signal Transduct Target Ther
Jeong YJ, Song IS, Jang SW.
europepmc   +1 more source