Results 251 to 260 of about 529,543 (309)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Perceived effectiveness of text-based tobacco control messages among Chinese young people: A mixed-methods study. [PDF]

Tob Induc Dis
Chen Y, Liu H, Li Z, Liu S, Xu J, Yue Y, Chan KS.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hybridization and Immunology in Animals: A Review. [PDF]

Ecol Evol
Graham CR, Thompson CW, Green DA, Speer KA.   +3 more
europepmc   +1 more source

A Combined Network Analysis for Orthorexia Nervosa, Obsessive Compulsive, and Eating Disorder Symptoms. [PDF]

Nutrients
Lombardo C, Cerolini S, Zagaria A, Vacca M, Rodgers RF.   +4 more
europepmc   +1 more source

Illness perception and self-management behaviours in adults with multimorbidity: a systematic review protocol. [PDF]

BMJ Open
Junger AL, Fonseca ES, Sousa ALL, Batista SRR.   +3 more
europepmc   +1 more source

Amblyopia in 2026: A State-of-the-Art Review of Multidimensional Phenotyping, Response Heterogeneity, and Clinical Considerations. [PDF]

Brain Sci
Ibrahimi D, García-Martínez JR.
europepmc   +1 more source

Prioritizing Clinically Relevant Criteria for Longitudinal Obesity Management: A Systemic Framework to Support Decision-Making. [PDF]

Obes Surg
Correa EL, Strobel R, Canciglieri Junior O, Schaefer JL.   +3 more
europepmc   +1 more source