Results 91 to 100 of about 242,339 (312)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An Interference Links Selection Method Based on Genetic Algorithm

Dianxin kexue, 2015
Focusing on interference alignment with partial interference links in multi-cell multiple input multiple output （MIMO）networks, an interference links selection scheme was proposed based on genetic algorithm.
Juan Meng, Li Hong, Yanan Li, Zhiming Han, Lili Guo   +4 more
doaj   +2 more sources

Public Transport Route Finding using a Hybrid Genetic Algorithm [PDF]

In this paper we present a public transport route finding solution based on a hybrid genetic algorithm. The algorithm uses two heuristics that take into consideration the number of trans-fers and the remaining distance to the destination station in order
Andreea DIOSTEANU, Liviu Adrian COTFAS
core   +1 more source

Event-based graphical monitoring in the EpochX genetic programming framework [PDF]

, 2013
EpochX is a genetic programming framework with provision for event management – similar to the Java event model – allowing the notification of particular actions during the lifecycle of the evolutionary algorithm. It also provides a flexible Stats system
Loïc Vaseux, Otero, Fernando E.B., Vaseux, Loic, Colin G. Johnson, Johnson, Colin G., Tom Castle, Castle, Tom, Fernando E.B. Otero   +7 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Enhanced Feature Selection Using Genetic Algorithm for Machine-Learning-Based Phishing URL Detection

Applied Sciences
In recent years, the importance of computer security has increased due to the rapid advancement of digital technology, widespread Internet use, and increased sophistication of cyberattacks.
Emre Kocyigit, Mehmet Korkmaz, Ozgur Koray Sahingoz, Banu Diri   +3 more
doaj   +1 more source

Application of a Genetic Algorithm to Variable Selection in Fuzzy Clustering [PDF]

In order to group the observations of a data set into a given number of clusters, an ?optimal? subset out of a greater number of explanatory variables is to be selected. The problem is approached by maximizing a quality measure under certain restrictions
Röver, Christian, Szepannek, Gero
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Evolutionary Synthesis of HVAC System Configurations: Algorithm Development. [PDF]

, 2008
This paper describes the development of an optimization procedure for the synthesis of novel heating, ventilating, and air-conditioning (HVAC) system configurations. Novel HVAC system designs can be synthesized using model-based optimization methods. The
Angelov, Plamen, Yi Zhang (9093), Jonathan Wright, Wright, Jonathan A., Richard Buswell, Plamen Angelov, Hanby, Victor I., Victor I. Hanby (7176788), Zhang, Yi, Yi Zhang, Jonathan Wright (1257306), Plamen Angelov (5037638), Richard Buswell (1249932), Buswell, Richard A., Victor Hanby   +14 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source