Results 121 to 130 of about 3,639,310 (295)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

External stakeholder risk response strategies selection in project portfolio

Heliyon
To improve the effectiveness of external stakeholder risks (ESRs) management in project portfolios (PPs), a portfolio-wide risk response approach is required.
Libiao Bai, Shuyun Kang, Fang Li, Ziwen Zhang, Jiayu Li, Xixi Luo   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Efficiency of S2 progeny selection strategies in popcorn

Crop Breeding and Applied Biotechnology, 2004
Selection among and within inbred families is a common procedure for developing corn inbred lines. The only alternative methods are selection among families, mass selection, or combined selection.
Joao Francisco dos Santos, José Marcelo Soriano Viana, Aloisio Alcantara Vilarinho, Tassiano Maxwell Marinho Câmara   +3 more
doaj  

Robust Access Points Selection Strategies for Dynamic Indoor Localization

IEEE Access
The proliferation of mobile devices has fueled the demand for indoor location-based services. Consequently, a plethora of techniques have emerged to facilitate object and device localization in indoor environments.
Aqilah Binti Mazlan, Yin Hoe Ng
doaj   +1 more source

Evolution Strategies and Threshold Selection [PDF]

, 2005
A hybrid approach that combines the (1+1)-ES and threshold selection methods is developed. The framework of the new experimentalism is used to perform a detailed statistical analysis of the effects that are caused by this hybridization. Experimental results on the sphere function indicate that hybridization worsens the performance of the evolution ...
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Bioindicators selection in the strategies for monitoring microplastic pollution

Ecological Indicators
Micro(nano)plastics (MNPs) are pervasive pollutants posing significant environmental and health risks. Selecting appropriate sentinel species to assess MNPs in terrestrial and aquatic environments involves considering factors such as species behavior ...
Paolo Pastorino, Damià Barceló
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source