Results 251 to 260 of about 166,195 (340)

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy. [PDF]

Neuron
Croce KR, Ng C, Pankiv S, Albarran E, Langfelder P, Ramos de Jesus A, Duncan GM, Wang N, Basile A, McHugh C, Litt NA, Li A, Friedman S, Cortes EP, Zody MC, Yang XW, Ding JB, Vonsattel JPG, Simonsen A, Housman DE, Wexler NS, Yamamoto A.   +21 more
europepmc   +1 more source

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations [PDF]

, 2016
et al,, Urano, Fumihiko
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Golgiphagy: a novel selective autophagy to the fore. [PDF]

Cell Biosci
Chen Y, Wu Y, Tian X, Shao G, Lin Q, Sun A.   +5 more
europepmc   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

The ribonuclease RNase T2 mediates selective autophagy of ribosomes induced by starvation in Saccharomyces cerevisiae. [PDF]

J Biol Chem
Minami A, Nishi K, Yamada R, Jinnai G, Shima H, Oishi S, Akagawa H, Aono T, Hidaka M, Masaki H, Kuzuyama T, Noda Y, Ogawa T.   +12 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process. [PDF]

Pharm Biol
Hu Z, Li Y, Yao N, Gan H, Zeng Q, Huang X, Huang D, Cai D, Chen Y.   +8 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

ADAR1 Promotes the Progression and Temozolomide Resistance of Glioma Through p62-Mediated Selective Autophagy. [PDF]

CNS Neurosci Ther
Zhang Y, Guo H, Bu J, Wang W, Wang L, Liu Z, Qiu Y, Wang Q, Zhou L, Liu X, Ma L, Wei J.   +11 more
europepmc   +1 more source