Results 61 to 70 of about 61,551 (239)
RoboticsThis paper focuses on the real-time obstacle avoidance and safe navigation of autonomous ground vehicles (AGVs). It introduces the Selective MPC-PF-PSO algorithm, which includes model predictive control (MPC), Artificial Potential Fields (APFs), and ...
Mingeuk Kim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Sensory perception drives food avoidance through excitatory basal forebrain circuits
eLife, 2019 Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have
Jay M Patel +8 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Media ideals and early adolescents’ body image: Selective avoidance or selective exposure?
Body Image, 2018 The present study combines selective exposure theory with body image coping literature to study effects of media internalization in early adolescence. The main objective was to explore how early adolescents selectively internalize media body ideals to manage their body image. To examine the role of media internalization in early adolescents' body image
Rousseau, Ann, Eggermont, Steven
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Larger error signals in major depression are associated with better avoidance learning
Frontiers in Psychology, 2011 The medial prefrontal cortex (mPFC) is particularly reactive to signals of error, punishment, and conflict in the service of behavioral adaptation and it is consistently implicated in the etiology of Major Depressive Disorder (MDD).
James F eCavanagh +4 more
doaj +1 more source
Exploring Selective Exposure and Selective Avoidance Behavior in Social Media
Proceedings of the 9th International Conference on Social Media and Society, 2018 This study investigates social media users' preferences of encountering or actively avoiding undesired content and conflicts in social interaction with others. Based on a nationwide survey (N=3706) conducted in Finland and using principal component analysis, we identify three different types of social media use in relation to online information sharing
Koivula Aki +3 more
openaire +2 more sources