Results 61 to 70 of about 94,303 (301)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Data_Sheet_2_Genomic Tools and Selective Breeding in Molluscs.xlsx
, 2018 The production of most farmed molluscs, including mussels, oysters, scallops, abalone, and clams, is heavily dependent on natural seed from the plankton.
Christopher M. Hollenbeck (576418) +1 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Data_Sheet_1_Genomic Tools and Selective Breeding in Molluscs.XLSX
, 2018 The production of most farmed molluscs, including mussels, oysters, scallops, abalone, and clams, is heavily dependent on natural seed from the plankton.
Christopher M. Hollenbeck (576418) +1 more
core +1 more source
Diversifying Selection in Plant Breeding
PLoS Biology, 2004 Natural variation rather than genetic modification - is this the way to achieve global food security?
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The genetics of selective breeding in Thoroughbred horses [PDF]
, 2020 This thesis examines the effects of selective breeding practices on the Thoroughbred horse population. The Thoroughbred horse breed was founded in the 18th century and the studbook has been closed since 1791, resulting in contemporary Thoroughbred horses
Todd, Evelyn Therese
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Selective Breeding in Organic Dairy Production
, 2009 Organic dairy farming started to take off in the early 1990s, when the European Union laid down organic standards for animal production. Until now, however, only incidental steps have been taken towards organic breeding and organic farmers mainly use ...
Nauta, W.J., Nauta, Wytze
core
The integration of ‘omic’ disciplines and systems biology in cattle breeding
, 2010 peer-reviewedEnormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches.
Diskin, Michael G. +13 more
core +1 more source