Results 111 to 120 of about 6,409,208 (237)

Differential expression of maternal plasma micrornas and their respective gene targets can predict early fetal growth restriction [PDF]

Fetal growth restriction (FGR) is a condition where the fetus does not reach its genetically predetermined size, affecting 1 in 10 pregnancies and contributing to up to 50% of all stillbirths before 34 weeks of gestation.
Bee Tan, Emmanuel Kolawole, Oscar Gronow, Aparna Duggirala, Duggirala, A., Wisniewska, A., Agnieszka Lovett, Gronow, O., Hu, J., Kolawole, E., Jiamiao Hu, Tan, B. K.   +11 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy.
MacDonald, TM, Walker, SP, Nijagal, B, Tong, S, Hannan, NJ, Perkins, AV, Kaitu’u-Lino, TJ, Pritchard, N, McKeating, DR, Bartho, LA   +9 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Congenital Bilateral Perisylvian Polymicrogyria in Twin-Twin Transfusion Syndrome and Selective Fetal Growth Restriction. [PDF]

Neurology, 2023
Rondagh M, Groene SG, de Vries LS, Lopriore E, Steggerda SJ.   +4 more
europepmc   +1 more source

A novel technique with cool-tip radiofrequency ablation for selective fetal reduction in complicated monochorionic twin

Taiwanese Journal of Obstetrics & Gynecology
Objective: To invent a novel method for selective fetal reduction in monochorionic (MC) twin using cool-tip radiofrequency ablation (RFA) and analysis the perinatal outcome.
Ting Yi Chu, Chih-Ping Chen, Pei-Chen Chen, Yu-Chen Chien, Hsing-Tse Yu, Liang-Ming Lo, T'sang-T'ang Hsieh, Steven W. Shaw   +7 more
doaj   +1 more source

The fetal kidney in intrauterine growth restriction: does renal sparing exist?

, 2023
reservedLa restrizione della crescita fetale (FGR) è una comune complicanza della gravidanza che si verifica quando il feto non riesce a raggiungere il proprio potenziale di crescita geneticamente determinato.
SALVADOR, MARTINA
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source