Results 91 to 100 of about 6,409,208 (237)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction [PDF]

, 2019
Background: Preeclampsia and fetal growth restriction share some pathophysiologic features and are both associated with placental insufficiency. Fetal cardiac remodeling has been described extensively in fetal growth restriction, whereas little is known ...
Sepulveda-Martinez, Alvaro, Gratacós, Eduard,, Crispi, Fatima,, Fatima Crispi, Miranda, Jezid, Olga Gomez, Gratacós, Eduard, Sepúlveda Martínez, Alvaro, Garcia-Otero, Laura,, Jezid Miranda, Garcia-Otero, Laura, Gomez, Olga, Kalapotharakos, Grigorios,, Vellvé, Kilian,, Crovetto, Francesca, Gomez, Olga,, Eduard Gratacós, Paules, Cristina, Crispi, Fatima, Youssef, Lina, Vellvé, Kilian, Grigorios Kalapotharakos, Miranda, Jezid,, García Otero, Laura, Alvaro Sepulveda-Martinez, Kilian Vellvé, Sepulveda-Martinez, Alvaro,, Youssef, Lina,, Francesca Crovetto, Lina Youssef, Kalapotharakos, Grigorios, Cristina Paules, Laura Garcia-Otero, Crovetto, Francesca,, Paules, Cristina,, Lund University.   +35 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intertwin umbilical vein diameter-to-abdominal circumference discordance in type 1 selective fetal growth restriction twins: association with risk of perinatal death in the smaller twin

Frontiers in Medicine
ObjectiveSelective fetal growth restriction (sFGR) is a common complication of monochorionic-diamniotic twin pregnancies, and there is no unified clinical standard for determining the optimal timing of intervention.
Minyu He, Minyu He, Minyu He, Minyu He, Chunyan Zhong, Chunyan Zhong, Chunyan Zhong, Chunyan Zhong, Jinwei Zhang, Jinwei Zhang, Jinwei Zhang, Jinwei Zhang, Peng Tu, Peng Tu, Peng Tu, Peng Tu, Suzhen Ran, Suzhen Ran, Suzhen Ran, Suzhen Ran, Jianjun Zheng, Jing Tang, Jing Tang, Jing Tang, Jing Tang   +24 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age [PDF]

, 2002
Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure ...
Shinebourne, EA, Syddall, H.E., Law, CM, Fayers, PM, A.W. Shiell, E.A. Shinebourne, Shinebourne, E.A., Shiell, AW, C.M. Law, Newsome, C.A., Martyn, C.N., M. de Swiet, Newsome, CA, Martyn, CN, de Swiet, M, H.E. Syddall, P.M. Fayers, C.N. Martyn, Syddall, HE, De Swiet, M., Fayers, P.M., C.A. Newsome, Law, C.M., Shiell, A.W.   +23 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Infant factors associated with fetal growth restriction.

, 2022
Infant factors associated with fetal growth restriction.
Shunichiro Tsuji (4816458), Shumpei Obata (11237777), Takahide Yanagi (5859359), Takashi Murakami (138867), Masahito Ohji (2560828), Riko Matsumoto (11824673), Masashi Kakinoki (6519578), Yoshihiro Maruo (8982578)   +7 more
core   +1 more source