Results 81 to 90 of about 6,409,208 (237)

Sildenafil citrate increases fetal weight in a mouse model of fetal growth restriction with a normal vascular phenotype.

PLoS ONE, 2013
Fetal growth restriction (FGR) is defined as the inability of a fetus to achieve its genetic growth potential and is associated with a significantly increased risk of morbidity and mortality. Clinically, FGR is diagnosed as a fetus falling below the 5(th)
Mark Robert Dilworth, Irene Andersson, Lewis James Renshall, Elizabeth Cowley, Philip Baker, Susan Greenwood, Colin Peter Sibley, Mark Wareing   +7 more
doaj   +1 more source

Maternal characteristics predisposing to fetal growth restriction

, 2017
Fetal growth restriction affects up to 10% of live-born infants representing a major cause of neonatal morbidity and mortality worldwide, being a significant risk factor for future adult health. A reduction of nutrient supply and oxygenation is the final
Francesca Parisi, Irene Cetin, Chiara Mandò   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Expectant Management of Monochorionic-Triamniotic Triplets Complicated by Selective In Utero Growth Restriction: Report of 2 Cases

Case Reports in Obstetrics and Gynecology, 2020
The optimal management of monochorionic-triamniotic (MCTA) triplet pregnancies is not clearly established, and there is no literature to guide management of MCTA complicated with selective intrauterine growth restriction (sIUGR).
Laurence Carmant, Sandrine Wavrant, Elisabeth Codsi   +2 more
doaj   +1 more source

Sonographic Placental Aspects in Fetal Growth Restriction [PDF]

Fetal growth restriction (FGR) is a complication diagnosed in about 10% of pregnancies and is associated with significant perinatal mortality and morbidity.
Nastasia SERBAN, Elena-Adriana GHELMENE, Manuela Cristina RUSSU   +2 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Complications in monochorionic twin pregnancies

Journal of Perinatal Medicine
Monochorionic placentas occur in two-thirds of identical (monozygotic) twin pregnancies and typically feature inter-fetal vascular anastomoses on their surface.
Klaritsch Philipp
doaj   +1 more source

The effects of asymmetric and symmetric fetal growth restriction on human capital development [PDF]

This paper explores the causal pathway by which poor fetal health translates into reducing educational attainment and earnings as an adult. Using insights from the medical literature, I decompose low birth weight infants into two distinct subtypes: a ...
Robinson, Joshua J
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sildenafil citrate therapy for IUGR and its effect on umbilical artery Doppler

Al-Azhar Assiut Medical Journal, 2020
Background Intrauterine growth restriction (IUGR) occurs when there is deficiency of gas exchange and nutrient delivery to the fetus not allowing it to thrive in utero. This happens because of maternal diseases that decrease oxygen-carrying capacity (e.g.
Abdel A.G.E.-D.T El-Darwish, Mahmoud A Badawy, Sally M.G Farghaly   +2 more
doaj   +1 more source