Results 51 to 60 of about 4,430,985 (208)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pregnancy Outcome After Selective Fetal Reduction in Dichorionic Twin Pregnancies. [PDF]

J Family Reprod Health, 2023
Rahimi Sharbaf F, Shafaat M, Lashgari S, Shirazi M, Sahebdel B, Golshahi F, Yousefi R, Dehghani Firoozabadi Z.   +7 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Perinatal outcome and timing of selective fetal reduction in dichorionic diamniotic twin pregnancies: a single-center retrospective study. [PDF]

Front Med (Lausanne), 2023
Zou G, Ji Q, Chen J, Zhang L, Sun Q, Shi Y, Yang Y, Zhou F, Wei X, Sun L.   +9 more
europepmc   +1 more source

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

, 2021
Poor maternal nutrition in pregnancy affects fetal development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remains ...
Moreno, Antonio J., Cunha-Oliveira, Teresa, Duarte, Ana I., Li, Cun, Santos, Maria S., Pereira, Susana P., Cox, Laura A, Nathanielsz, Peter W., Oliveira, Paulo J., Baldeiras, Inês, Martins, João D., Santos, Maria S, Cox, Laura A., Tavares, Ludgero C., Maloyan, Alina, Nijland, Mark J., Pereira, Susana P   +16 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Trends of Selective Fetal Reduction and Selective Termination in Multiple Pregnancy, in England and Wales: a Cross-Sectional Study. [PDF]

Reprod Sci, 2022
Sam S, Tai-MacArthur S, Shangaris P, Sankaran S.   +3 more
europepmc   +1 more source

Impact of maternal obesity and diabetes on fetal pancreatic development

, 2017
The global epidemics of obesity and type 2 diabetes (T2D) are serious threats to human health and health-care expenses. Although genetics is an important factor, it does not explain this dramatic increase that involves environmental factors such as ...
Iessi, Isabela [UNESP], Damasceno, Débora C. [UNESP], Nielsen, Jens H., Jaksch, Caroline   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Fetoscopic Laser Ablation for the Selective Fetal Reduction in Twin-Twin Transfusion Syndrome Stage II-IV: The Experience of a New Fetal Medicine Center. [PDF]

Int J Womens Health, 2022
Anh ND, Hung HS, Sim NT, Ha NTT, Nguyen DL, Bac ND, Tong HV, Ville Y, Thuong PTH.   +8 more
europepmc   +1 more source