Results 81 to 90 of about 59,761 (296)

Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use

Neuropsychiatric Disease and Treatment, 2012
Mandeep Singh, Thomas L SchwartzSUNY Upstate Medical University, Psychiatry Department, Syracuse, NY, USABackground: Vilazodone is the latest approved antidepressant available in the United States.
Singh M, Schwartz TL
doaj  

Methylphenidate, but not citalopram, decreases impulsive choice in rats performing a temporal discounting task

Frontiers in Psychiatry
IntroductionDrugs targeting monoamine systems remain the most common treatment for disorders with impulse control impairments. There is a body of literature suggesting that drugs affecting serotonin reuptake and dopamine reuptake can modulate distinct ...
Miranda F. Koloski, Miranda F. Koloski, Miranda F. Koloski, Alyssa Terry, Noelle Lee, Dhakshin S. Ramanathan, Dhakshin S. Ramanathan, Dhakshin S. Ramanathan   +7 more
doaj   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Analytical methods for determination of selective serotonin reuptake inhibitor antidepressants

Reviews in Analytical Chemistry, 2011
Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression. SSRIs are classified as fluoxetine, paroxetine, escitalopram, citalopram, sertraline, and fluvoxamine.
Şentürk Zühre, Saka Cafer, Teğin İbrahim   +2 more
doaj   +1 more source

Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine

Molecular Brain, 2011
Background Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat mood and anxiety disorders. However, neuronal bases for both beneficial and adverse effects of SSRIs remain poorly understood.
Kobayashi Katsunori, Ikeda Yumiko, Suzuki Hidenori   +2 more
doaj   +1 more source

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]

, 2017
BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette, Connor, Kathryn M, Herring, W Joseph, Hutzelmann, Jill, Krystal, Andrew D, Lines, Christopher, Michelson, David, Snavely, Duane, Thase, Michael, Trivedi, Madhukar H   +9 more
core   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Selective serotonin reuptake inhibitor (SSRI) antidepressants, prolactin and breast cancer

Frontiers in Oncology, 2012
Selective serotonin reuptake inhibitors (SSRIs) are a widely prescribed class of anti-depressants. Laboratory and epidemiologic evidence suggests that a prolactin-mediated mechanism secondary to increased serotonin levels at neuronal synapses could lead ...
Janet eAshbury, Linda eLévesque, Patty eBeck, Kristan eAronson   +3 more
doaj   +1 more source

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database [PDF]

, 2015
Objective To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. Design Cohort study.
Arthur, Antony, Coupland, Carol, Hill, Trevor, Hippisley-Cox, Julia, Moore, Michael, Morriss, Richard   +5 more
core   +2 more sources

Implementation of OMOP and ConcePTION Common Data Models in CPRD GOLD: Risk of Bleeding and Cardiovascular Outcomes From Anticoagulant Use

Clinical Pharmacology &Therapeutics, EarlyView.
The impact of the choice of common data model (CDM) approach on the study results in a real‐world evidence (RWE) study is unknown. We aimed to determine potential differences in the results of an RWE study when data were mapped to two different CDMs, ConcePTION and OMOP. With the same instance of CPRD GOLD, data were mapped to both CDMs. Using the same
Nicholas B. Hunt, Patrick Souverein, Marloes Bazelier, Nicola Barclay, Antonella Delmestri, Miriam Sturkenboom, Daniel Prieto‐Alhambra, Helga Gardarsdottir, Olaf Klungel   +8 more
wiley   +1 more source