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Selective Serotonin Reuptake Inhibitors
2018The first antidepressants were created by chance but brought the idea that central serotonin agonism produced an antidepressant effect. SSRIs were the first class of psychotropic medications to be rationally designed, meaning that researchers intended to utilize a specific mechanism of action while avoiding adverse effects.
Dee, Lochmann, Tara, Richardson
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Clastogenicity of selective serotonin-reuptake inhibitors
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2004Selective serotonin-reuptake inhibitors (SSRIs) are used in the treatment of various forms of psychiatric disorders. Preclinical studies in laboratory animals have indicated that SSRIs were not genotoxic, but clear results from in vitro testing of SSRIs in a human cell system are currently scarce.
Gokay, Bozkurt +8 more
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Pharmacokinetics of selective serotonin reuptake inhibitors
Pharmacology & Therapeutics, 2000The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile. They differ, however, in their pharmacokinetic properties. Under steady-state concentrations, their half-lives range between 1 and 4 days for fluoxetine (7 and
C, Hiemke, S, Härtter
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The pharmacogenetics of the selective serotonin reuptake inhibitors
The Clinical Investigator, 1993Citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline are selective serotonin reuptake inhibitors (SSRIs), which are thought to act as antidepressants through their ability to inhibit presynaptic serotonin reuptake in the brain. The elimination of the SSRIs proceeds predominantly via oxidation catalyzed by cytochrome P450 in the liver ...
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Selective serotonin reuptake inhibitors
Nurse Prescribing, 2010Selective serotonin reuptake inhibitors (SSRIs) are used widely for the treatment of depression and anxiety disorders, and different SSRIs have different licence indications. They prevent the reuptake of serotonin in the synapse between nerve cells; they should be used with caution in children and adolescents owing to the possible side-effect of an ...
Michael M. Morgan +199 more
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Not So Selective Serotonin Reuptake Inhibitors
The Journal of Clinical Psychiatry, 1998Venlafaxine norepinephrine reuptake dopamine reuptake BRAINSTORMS is a monthly section of The Journal of Clinical Psychiatry aimed at providing updates of novel concepts emerging from the neurosciences that have relevance to the practicing psychiatrist.
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Selective Serotonin Reuptake Inhibitors
2016Selective serotonergic reuptake inhibitors (SSRIs) are a class of medications used frequently to address issues related to stroke and post-stroke recovery. Health care providers who care for stroke patients will need to familiarize themselves with their applications in stroke treatment.
Ali Saad +2 more
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Selective Serotonin Reuptake Inhibitors
PharmacoEconomics, 1996Depression is a common and significant health problem associated with impairment in a patient's ability to function in their role (e.g. student, worker, home-maker), and may have a fatal outcome in the case of suicide. Recently there has been progress in developing new antidepressant medications, such as the selective serotonin reuptake inhibitors ...
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Selective Serotonin Reuptake Inhibitors and Autism
American Journal of Therapeutics, 2016Tina J, Walch, Amanda, Tinkelman
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