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The Pharmacogenomics of Selective Serotonin Reuptake Inhibitors
Pharmacogenomics, 2022Antidepressant medications are frequently used as the first line of treatment for depression. However, their effectiveness is highly variable and influenced by genetic factors. Recently, pharmacogenetic studies, including candidate-gene, genome-wide association studies or polygenic risk scores, have attempted to uncover the genetic architecture of ...
Luis M García-Marín +5 more
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Selective Serotonin Reuptake Inhibitors in Pregnancy
Current Medicinal Chemistry, 2012The use of antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs), during pregnancy is rapidly increasing. To date, the effects of SSRI on pregnant women and fetuses are controversial and still a matter of debate. Although a number of studies have shown that these antidepressants are not teratogenic, some of them have reported an
Bellissima, V. +3 more
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Selective Serotonin-Reuptake Inhibitors: An Update
Harvard Review of Psychiatry, 1999Selective serotonin-reuptake inhibitors (SSRIs), including fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram, represent an important advance in the pharmacotherapy of mood and other disorders. They are chemically unrelated to tricyclic, heterocyclic, and other first-generation antidepressants.
P S, Masand, S, Gupta
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Pharmacokinetics of selective serotonin reuptake inhibitors
Pharmacology & Therapeutics, 2000The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile. They differ, however, in their pharmacokinetic properties. Under steady-state concentrations, their half-lives range between 1 and 4 days for fluoxetine (7 and
C, Hiemke, S, Härtter
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Selective Serotonin Reuptake Inhibitor Exposure
Topics in Companion Animal Medicine, 2013Many antidepressants inhibit serotonin or norepinephrine reuptake or both to achieve their clinical effect. The selective serotonin reuptake inhibitor class of antidepressants (SSRIs) includes citalopram, escitalopram (active enantiomer of citalopram), fluoxetine, fluvoxamine, paroxetine, and sertraline.
Kevin T, Fitzgerald, Alvin C, Bronstein
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Selective Serotonin Reuptake Inhibitors
2018The first antidepressants were created by chance but brought the idea that central serotonin agonism produced an antidepressant effect. SSRIs were the first class of psychotropic medications to be rationally designed, meaning that researchers intended to utilize a specific mechanism of action while avoiding adverse effects.
Dee, Lochmann, Tara, Richardson
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Clastogenicity of selective serotonin-reuptake inhibitors
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2004Selective serotonin-reuptake inhibitors (SSRIs) are used in the treatment of various forms of psychiatric disorders. Preclinical studies in laboratory animals have indicated that SSRIs were not genotoxic, but clear results from in vitro testing of SSRIs in a human cell system are currently scarce.
Gokay, Bozkurt +8 more
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Selective serotonin reuptake inhibitors
Nurse Prescribing, 2010Selective serotonin reuptake inhibitors (SSRIs) are used widely for the treatment of depression and anxiety disorders, and different SSRIs have different licence indications. They prevent the reuptake of serotonin in the synapse between nerve cells; they should be used with caution in children and adolescents owing to the possible side-effect of an ...
Michael M. Morgan +199 more
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Selective Serotonin-Reuptake Inhibitors [PDF]
, 2002 Depresija je česta bolest, koja može biti teška, a katkad i ugroziti život oboljele osobe. Zahvaljujući porastu broja novih antidepresiva u posljednjih 15 godina, mogućnosti farmakološkog liječenja depresije su proširene.
Marina Šagud +5 more
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