Results 81 to 90 of about 85,863 (303)

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Drug interactions and possible serotonin syndrome in a patient with fibromyalgia

Vitae, 2014
Depression associated with fibromyalgia can be treated with selective serotonin reuptake inhibitors (SSRI) as fluoxetine, paroxetine or citalopram; or with serotonin–norepinephrine reuptake inhibitors (duloxetine or milnacipran).
Patricia de Carvalho MASTROIANNI, Fabiana Rossi VARALLO, Manuel MACHUCA   +2 more
doaj  

Skin eruptions related with selective serotonin reuptake inhibitors

Psychiatry and Clinical Psychopharmacology, 2021
Objective: The aim of the present study was to provide clinical data regarding clinical and sociodemographic features of individuals who were admitted to our clinic for skin rash during treatment with selective serotonin reuptake inhibitors (SSRI ...
Ayse Suleyman, Funda Suleyman, Ilyas Kaya, Behiye Alyanak   +3 more
doaj  

Antidepressants versus placebo for depression in primary care [PDF]

, 2009
Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce, Blashki, Grant, Elley, C. Raina, Fishman, Tana, Goodyear-Smith, Felicity A., Kenealy, Tim, Kerse, Ngaire, MacGillivray, Stephen   +7 more
core   +3 more sources

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Comparing Attention Bias Modification With Selective Serotonin Reuptake Inhibitors in Patients With Obsessive-Compulsive Disorder

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2019
Background and Aim Obsessive-Compulsive Disorder (OCD) is the fourth most common psychiatric disorder. It consists of symptoms, including intrusive thoughts, rituals, behaviors, preoccupations, and compulsions.
Khadijeh Mohsenpourian, Mostafa Nokani, Hamidreza Jamilian, Mohsen Ghasemi   +3 more
doaj  

Selective serotonin reuptake inhibitors for fibromyalgia syndrome

São Paulo Medical Journal
BACKGROUND: Fibromyalgia is a clinically well-defined chronic condition with a biopsychosocial aetiology. Fibromyalgia is characterized by chronic widespread musculoskeletal pain, sleep problems, cognitive dysfunction, and fatigue. Patients often report
Brian Walitt, Gerard Urrútia, María Betina Nishishinya, Sarah E. Cantrell, Winfried Häuser   +4 more
doaj   +1 more source

Selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors use and risk of fractures in adults: a systematic review and meta-analysis [PDF]

, 2018
Objective: to evaluate the association between SSRI and SNRI use and risk of fractures in older adults. Methods: We systematically identified and analyzed observational studies comparing SSRI/SNRI use for depression with non-SSRI/SNRI use with a ...
Abrahamsen, Adachi, Ali, Bakken, Bali, Bolton, Brand, Carriere, Cheng, Collins, Coupland, Coupland, De Groot, Diem, Donaldson, Ensrud, Ensrud, Eom, Ferguson, French, Friede, Gagne, Gebara, Hanyu, Higgins, Hubbard, Kontopantelis, Lanteigne, Lewis, Liu, Moher, Moura, Nelson, Oderda, Olfson, Pacher, Pouwels, Rabenda, Rabenda, Redrobe, Richards, Rizzoli, Schink, Schneeweiss, Sheu, Sheu, Souverein, Spangler, Takkouche, Thapa, Verdel, Vestergaard, Vestergaard, Vestergaard, Wang, Wu, Ziere, Zucker   +57 more
core   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Effects of milnacipran on binge eating – a pilot study

Neuropsychiatric Disease and Treatment, 2008
Shun’ichi Noma1, Teruhisa Uwatoko1, Haruka Yamamoto2, Takuji Hayashi11Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 2Department of Psychiatry, Toyooka Hospital, Hyogo, JapanAbstract: Selective serotonin ...
Shun’ichi Noma, Teruhisa Uwatoko, Haruka Yamamoto, Takuji Hayashi   +3 more
doaj