Results 71 to 80 of about 1,626,624 (288)

Selective serotonin reuptake inhibitors versus tricyclic and heterocyclic antidepressants: comparison of drug adherence.

, 2000
BACKGROUND: Selective serotonin reuptake inhibitors are thought to have better discontinuation rates (i.e. less people dropping out) than tricyclic and heterocyclic antidepressant drugs.
Churchill, R, Hardy, R, C Barbui, Freemantle, N, Hardy, Rowan, R Churchill, N Freemantle, Lewis, G, Boynton, J, JR Geddes, Barbui, C, Mason, J M, Eccles, MP, G Lewis, Eccles, M P, JM Mason, Freemantle, Nick, Geddes, John, MP Eccles, Geddes, JR, J Boynton, Mason, JM, Hotopf, M, M Hotopf, Geddes, J R, R Hardy   +25 more
core   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

Serotonin syndrome: An often-neglected medical emergency

Journal of Family and Community Medicine
Optimum serotonin level in the serotonergic synapses of the central nervous system (CNS) is related to mood, behavior, and sleep. Serotonin syndrome (SS) is a rare yet very dangerous adverse effect resulting from increased serotonin in CNS. The diagnosis
Ahmed Badar
doaj   +1 more source

Investigation of a role for noradrenaline in the neurochemical and behavioural effects of an established and putative target for antianxiety/antidepressant drugs: a microdialysis and behavioural study in rats and NK1 receptor knockout mice. [PDF]

, 2005
The precise neurochemical effects of antidepressants that underlie their efficacy remain unclear. Many antidepressants modulate noradrenaline transmission in vivo.
Stewart, R.J.
core  

WITHDRAWN: Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs).

, 2006
BACKGROUND: Selective serotonin reuptake inhibitors are thought to have better discontinuation rates (i.e. less people dropping out) than tricyclic and heterocyclic antidepressant drugs.
Churchill, R, Matthew Hotopf, Hardy, R, Rebecca Hardy, Freemantle, N, Nick Freemantle, Martin Eccles, Geddes, JR, John Geddes, Lewis, G, Corrado Barbui, Glyn Lewis, Boynton, J, J Boynton, Barbui, C, Mason, JM, Hotopf, M, Eccles, MP, Rachel Churchill, James Mason   +19 more
core   +1 more source

On the Effects of Serotonin Reuptake Inhibitors in Major Depression [PDF]

, 2019
This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS).
Hieronymus, Fredrik
core   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects [PDF]

, 2015
BACKGROUND: The neurobiological changes underlying depression resistant to treatments remain poorly understood, and failure to respond to selective serotonin reuptake inhibitors may result from abnormalities of neurotransmitter systems that excite ...
Provensi, Gustavo, Galeotti, Nicoletta, Benetti, Fernando, CASSANO, TOMMASO, Blandina, Patrizio, Corradetti, Renato, Passani, Maria Beatrice, Munari, Leonardo   +7 more
core   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

Drug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum, Shao‐Hsin Hung, Meng‐Tsang Hsieh, Mei‐Chich Hsu, William Chih‐Wei Chang   +4 more
wiley   +1 more source

The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents

IBRO Reports, 2019
This study was designed with the rational aim of discussing the emerging antidepressant agents that are likely to bring positive landmark, tremendous improvement and significant impact to the management of patients with depression disorders.
Olumuyiwa John Fasipe
doaj   +1 more source