Results 51 to 60 of about 1,626,624 (288)

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

open access: yesAutism Research, EarlyView.
ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non‐autistic males and females in the United Kingdom (UK) from 1997 to 2023.
Aws Sadik   +7 more
wiley   +1 more source

Noticeable changes in diaphoresis severity following pain management medication adjustments in a complex regional pain syndrome patient [PDF]

open access: yesAnesthesia and Pain Medicine
Background Serotonin syndrome results from the use of serotonergic agents that elevate intrasynaptic serotonin level or excessively activate serotonin postsynaptic receptors.
Joon Hee Lee   +2 more
doaj   +1 more source

A Case of Comorbid PTSD and Posttraumatic OCD Treated with Sertraline-Aripiprazole Augmentation

open access: yesCase Reports in Psychiatry, 2020
Several studies report on traumatic history in Obsessive Compulsive Disorder (OCD) and comorbidity between Posttraumatic Stress Disorder (PTSD) and OCD.
Rodolfo Rossi   +4 more
doaj   +1 more source

Galactorrhea with antidepressants: A case series

open access: yesIndian Journal of Psychiatry, 2018
Galactorrhoea is a rare but distressing, and often embarrassing adverse effects of selective serotonin reuptake inhibitors (SSRIs) treatment. Here we report three cases that developed galactorrhoea with combination of SSRIs or combination of SSRI and ...
Navratan Suthar   +3 more
doaj   +1 more source

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus   +6 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili   +6 more
wiley   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) and osteoporosis: A target trial emulation using real-world data

open access: yes, 2023
A target trial emulation using real-world data to study the impact of the selective serotonin reuptake inhibitors (SSRIs) sertraline, citalopram and escitalopram on the risk of ...
Michael Berk   +3 more
core   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire   +3 more
wiley   +1 more source

Antidepressant-induced sexual dysfunction

open access: yesSouth African Family Practice, 2009
Depression and sexual dysfunction are both common in the general population. When they co-exist, they have the potential to impact negatively on each other in a bidirectional manner.
Kim Outhoff
doaj   +1 more source

Environmental impact of antidepressants: Is a new prescription framework possible?

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Antidepressants such as venlafaxine and sertraline pose high risks to water ecosystems. As depressive disorders and other mental health conditions become increasingly prevalent worldwide, prescription and environmental presence of these pharmaceuticals continue to rise. This study explores the practical viability of a new framework for prescribing
Matilde Bianconi   +5 more
wiley   +1 more source

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