Results 201 to 210 of about 1,752,062 (351)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Tuning NiCu/AlO(OH) catalysts for optimal glycerol hydrogenolysis to 1,2-propanediol. [PDF]

RSC Adv
Ghorbani A, Dalai AK.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Highly efficient CO₂ hydrogenation to long-chain linear α-olefins <i>via</i> CO intermediate enrichment over Na/FeMn/ZrO₂ catalysts. [PDF]

Chem Sci
Wang K, Liu T, Hai P, Fujii S, Liu C, Song H, Zhu C, Liu G, Zhang J, Wang ZJ, Tsubaki N.   +10 more
europepmc   +1 more source

Electricity-driven site-selective deuteration of pharmaceuticals

Yujie Sun, Yujie Sun, Guan‐Qun Han, Guan‐Qun Han, Guodong Li, G. Li, Yujie Sun   +6 more
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

ZrO₂ supported Fe-based catalysts for direct synthesis of light olefins via CO₂ hydrogenation. [PDF]

Sci Rep
Kraleva E, Saladino ML, Giordano C, Ponterio RC, Armbruster U.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Size Selectivity of Square-Mesh Codends in Stownet for <i>Coilia mystus</i> in the South China Sea. [PDF]

Animals (Basel)
Yan L, Zhu Q, Zhang P, Li J, Yang B, Wang T, Hua C.   +6 more
europepmc   +1 more source

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

, 2008
Stanley D. Chamberlain, Anikó M. Redman, Joseph W. Wilson, Felix Deanda, J. Brad Shotwell, Roseanne Gerding, Huangshu Lei, Bin Yang, Kirk L. Stevens, Anne M. Hassell, Lisa M. Shewchuk, M. Anthony Leesnitzer, Jeffery L. Smith, Peter Sabbatini, Charity Atkins, Arthur Groy, Jason L. Rowand, Rakesh Kumar, Robert A. Mook, Ganesh S. Moorthy, Samarjit Patnaik   +20 more
openalex   +1 more source