Results 251 to 260 of about 1,752,062 (351)

An efficient method for site-selective boronation of peptides and proteins applied in magnified bacterial imaging

Vishal Rai, Anupam Bandyopadhyay
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase. [PDF]

Nucleic Acids Res
Lan M, Xu L, Han Y, Cui T, Qiao Z, Teng YB, Wang N, Bao H.   +7 more
europepmc   +1 more source

Safety and efficacy of envudeucitinib, a highly selective, oral allosteric TYK2 inhibitor, in patients with moderate-to-severe plaque psoriasis: Results from the 52-week open-label extension period of the phase 2 STRIDE study

Kim Papp, Shahram Jacobs, Howard Sofen, Michael Bukhalo, Elisa Muscianisi, Grace Ma, Gabriel Lau, Michelle Bettinger, Roman G. Rubio, Elena Hitraya, Andrew Blauvelt   +10 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Iridium catalyzed regiodivergent functionalization of all three C-H bonds of arenes by a single ligand. [PDF]

Nat Commun
Das J, Hoque ME, Hassan MMM, Guria S, Dey S, Ma J, Deng Z, Liang Y, Chattopadhyay B.   +8 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Interlayer-Tailored Alkyl-MXenes for Selective Electrochemical Lithium-Ion Extraction. [PDF]

ACS Energy Lett
Kök C, Eisawi K, Ruthes JGA, Tan B, Quade A, Naguib M, Presser V.   +6 more
europepmc   +1 more source

Podoplanin hetero-insufficiency demonstrates congenital protein-losing enteropathy by inflammation in the jejunum: NO synthase inhibitor may become a selective tool for pharmacological therapy [PDF]

Toshio Ohhashi, Mieko Takasaka, Nagaharu Tsukiji, Tomomi Watanabe‐Asaka, Moyuru Hayashi, Daisuke Maejima, Maki Kaidoh, Yumiko Yokoyama, Katsue Suzuki‐Inoue, Yoshiko Kawai   +9 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source