Results 281 to 290 of about 1,752,062 (351)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Mitogen-activated protein kinase kinase 4 (MKK4) as a promising therapeutic target in liver diseases: a review. [PDF]

J Enzyme Inhib Med Chem
Liu P, Liu Y, Cheng L, Bao T, Li J, Wu J, Han J, Li T, Zhang D.   +8 more
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Synthesis and CO₂/N₂ Separation Performance Analysis of Mixed Matrix Membrane (MMM) Based on Different Bimetallic Metal-Organic Frameworks (Ni-Cu-MOF-74, Ni-Co-MOF-74, and Ni-Zn-MOF-74). [PDF]

Membranes (Basel)
Ahsan S, Ahsan M, Noor T, Farrukh S, Roafi H.   +4 more
europepmc   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation. [PDF]

MAbs
Grace J, Colin PY, Foxler D, Haynes W, Howsham C, Kassimatis L, Mavrogonatou L, Mighell R, McClory J, Mullin M, Ogola T, Townsend A, Ravi S, Wossnig L, van Heeke G.   +14 more
europepmc   +1 more source

The British Council and rural development: a selective report following a visit to South India

, 2010
Robert Chambers
openalex   +1 more source

Andean bear tree selectivity for scent-marking in Ecuadorian cloud forests

Eva Filipczyková, Melanie Clapham, R Horn, Owen T. Nevin, João Filipe Cardozo de Barros, Aleš Vorel   +5 more
openalex   +1 more source

RetINaBox: A Hands-On Learning Tool for Experimental Neuroscience. [PDF]

eNeuro
Bettler B, Arias Armas F, Cianfarano E, Bordonaro V, Liu MQ, Loukine M, Wan M, Villemain A, Richards BA, Trenholm S.   +9 more
europepmc   +1 more source

Polysulfone Membranes: Here, There and Everywhere. [PDF]

Membranes (Basel)
Verdugo P, Gulaczyk I, Olkiewicz M, Montornes JM, Woźniak-Budych M, Pniewski FF, Hołyńska-Iwan I, Tylkowski B.   +7 more
europepmc   +1 more source