Results 81 to 90 of about 205,586 (228)
Molecules, 2020 A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ1–42 aggregation as potential treatments for Alzheimer’s ...
Suresh K. Bowroju +7 more
doaj +1 more source
Solid-State Effects on the Optical Excitation of Push-Pull Molecular J-Aggregates by First-Principles Simulations [PDF]
, 2018 open3noopenGuerrini, Michele; Calzolari, Arrigo; Corni, StefanoGuerrini, Michele; Calzolari, Arrigo; Corni ...
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Tipping to an Aggregated State by Mesoscale Convective Systems
Journal of Advances in Modeling Earth SystemsRadiative‐convective equilibrium simulations were suggested to resist self‐aggregation within a linearly stable regime at low surface temperatures. Recent numerical work shows that this linearly stable regime can rapidly transition to an aggregated state
I. L. Kruse, R. Fiévet, J. O. Haerter
doaj +1 more source
Statistical Mechanical Treatments of Protein Amyloid Formation [PDF]
, 2013 Protein aggregation is an important field of investigation because it is closely related to the problem of neurodegenerative diseases, to the development of biomaterials, and to the growth of cellular structures such as cyto-skeleton. Self-aggregation of
Schreck, John S., Yuan, Jian-Min
core +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Photocatalytic degradation of ketorolac tromethamine (KTC) drug in aqueous phase using prepared Ag-doped ZnO microplates [PDF]
, 2017 In this study, Ag-doped ZnO microplates were prepared via precipitation technique and further characterized by FESEM, EDS, XRD, FTIR, TGA, XPS, UV-DRS and RT-PL techniques.
Ibhadon, Alex +2 more
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Collective chemotactic dynamics in the presence of self-generated fluid flows
, 2012 In micro-swimmer suspensions locomotion necessarily generates fluid motion, and it is known that such flows can lead to collective behavior from unbiased swimming. We examine the complementary problem of how chemotaxis is affected by self-generated flows.
Enkeleida Lushi +4 more
core +2 more sources