Results 41 to 50 of about 337,087 (199)

Graphene Oxide/Ferrocene-Containing Polymer/Gold Nanoparticle Triple Nanocomposite

Nanomaterials, 2019
A facile strategy to prepare GO-based nanocomposites with both gold nanoparticles (AuNPs) and ferrocene (Fc) moieties was developed. The surface of GO was modified with PFcMAss homopolymer by surface-initiated atom transfer radical polymerization of a ...
Wenhao Qian, Tao Song, Mao Ye, Haiyan Zhang, Chun Feng, Guolin Lu, Xiaoyu Huang   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Photogeneration of Hydrogen in Water via Self‐Assembly‐Induced Colloidal Covalent Organic Framework Particles

Small Science
The synthesis of colloidal imine‐linked Covalent Organic Framework nanoparticles using a polymeric growth‐blocking agent that facilitates both in situ colloidal stabilization and size control. This new surfactant‐free method, called Self‐Assembly‐Induced
Axelle Larrieu, Sabuj Kanti Das, Aurelien Viterisi, Laurent Billon   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Thiazolothiazole‐Based Quinoidal Compounds for High‐Performance n‐Channel Organic Field‐Effect Transistors with Low‐Cost Metal Electrodes

Advanced Electronic Materials, 2020
Thiazolothiazole‐based quinoidal molecules B1 and B2 are designed and synthesized. B1 and B2 have low‐lying lowest unoccupied molecular orbital energy levels of −4.47 and −4.41 eV, respectively.
Yan Feng, Xiaolan Qiao, Guangcheng Ouyang, Guohua Liu, Hongxiang Li   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Eliminating the Heart from the Curcumin Molecule: Monocarbonyl Curcumin Mimics (MACs)

Molecules, 2014
Curcumin is a natural product with several thousand years of heritage. Its traditional Asian application to human ailments has been subjected in recent decades to worldwide pharmacological, biochemical and clinical investigations.
Dinesh Shetty, Yong Joon Kim, Hyunsuk Shim, James P. Snyder   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Biomimetic mineralization of diatom exoskeleton for sustainable pH-sensitive colored chitosan/silica hybrid self-supported films

Materials & Design
A gentle bio-inspired approach to the biosilicification occurring in diatom frustule is proposed to develop, at room temperature and without addition of a co-solvent, self-supported hybrid organic/inorganic films with pH-sensitive properties.
Sandra Castanié, Laurent Billon
doaj   +1 more source