Results 61 to 70 of about 148,093 (236)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Scent whisper [PDF]

, 2006
Scent Whisper is a jewellery set integrated with wireless sensor networks that offer social and therapeutic value in a desirable context. The jewellery incorporates sensors and microfluidics to initiate fragrance delivery, depending on the sensor ...
Jenkins, Gareth, Manz, Andreas, Tillotson, Jenny   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Si photocathode with Ag-supported dendritic Cu catalyst for CO2 reduction [PDF]

, 2019
Si photocathodes integrated with Ag-supported dendritic Cu catalysts are used to perform light-driven reduction of CO2 to C2 and C3 products in aqueous solution.
Ager, JW, Beeman, JW, Bullock, J, Eichhorn, J, Gurudayal, Javey, A, Mathews, N, Toma, FM, Towle, C, Wang, H   +9 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Ultrafast and Stable Organic Single‐Crystal Vertical Phototransistor for Self‐Powered Photodetection and High‐Speed Imaging

Advanced Electronic Materials, 2023
Organic semiconductor crystals herald new opportunities for fabricating high‐performance optoelectronic devices, due to their intrinsic properties including outstanding charge transport properties, long exciton lifetime, and diffusion length.
Yuting Zhang, Shuchao Qin, Qianqian Du, Yuquan Gan, Jing Zhao, Mengru Li, Xialian Zheng, Anran Wang, Yunlong Liu, Shuhong Li, Ruixin Dong, Zhonghui Nie, Cailong Liu, Wenjun Wang, Fengqiu Wang   +14 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A High Responsivity and Photosensitivity Self‐Powered UV Photodetector Constructed by the CuZnS/Ga2O3 Heterojunction

Advanced Materials Interfaces, 2023
Fabricating a heterojunction photodetector is efficient to take advantage of the built‐in electric field formed by heterojunction and thus improve the performance of photodetector.
Zunxian Lv, Shiqi Yan, Wenxiang Mu, Yiyuan Liu, Qian Xin, Yang Liu, Zhitai Jia, Xutang Tao   +7 more
doaj   +1 more source

3D Energy Harvester Evaluation [PDF]

, 2013
This paper discusses the characterization and evaluation of an MEMS based electrostatic generator, a part of the power supply unit of the self-powered microsystem[1,2,3].
Husak, M., Janicek, V.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source