Results 61 to 70 of about 6,364,062 (240)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Untangling the web : reports of self-concept, academic motivation and perceived discrimination for indigenous secondary students

open access: yes, 2006
Recently, a new direction has emerged within the field of educational psychology that has sought to address the inequities between Indigenous Australian students and the wider Australian student population.
Craven, Rhonda, Bodkin-Andrews, Gawaian
core  

Development and preliminary validation of a self-perceived burden scale for individuals with chronic illness.

open access: yes, 2000
Caregiver burden has been studied at length in caregivers of many populations of chronically ill people. The other side of the informal caregiving relationship is the recipient's response to aid, especially their perceptions of the burden they pose to ...
Cousineau, Natalie Janine.
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Self-esteem as an adaptive resource during a transitional event

open access: yes, 2004
Self-esteem is a critical component of success in any high performance environment. A high level of self esteem is not only a consequence of success at an elite level, it also plays an important role as a buffer against negative events which may occur as
Tremayne, Patsy   +2 more
core  

Intolerance of uncertainty, cognitive fusion, coping self‐efficacy and self‐perceived burden in patients diagnosed with cancer

open access: yes, 2023
BackgroundAs the proportion of older people worldwide increases, cancer cases and deaths from cancer are rising. Suffering from cancer has a profound impact on the daily lives of patients and their families. Cancer patients often perceive themselves as a
Seyede Elham Mousavi   +3 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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