Results 201 to 210 of about 979,898 (268)

Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors. [PDF]

Neuropsychopharmacology
Kallupi M, de Guglielmo G, Carrette LLG, Simpson S, Kononoff J, Kimbrough A, Smith LC, Shankar K, Avelar A, Conlisk D, Brennan M, Tieu L, Sedighim S, Boomhower B, Maturin L, Fannon MJ, Martinez A, Crook C, Dirik S, Velarde N, Schweitzer P, Bonnet-Zahedi S, Sneddon E, Plasil S, Morgan AA, Othman DN, Sichel B, Peng B, Chitre AS, Polesskaya O, Lau J, Vang A, Solberg Woods LC, Palmer AA, George O.   +34 more
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Ethanol self-administration reduced the efficacy of a behavioral intervention to decrease cocaine choice in socially housed male and female monkeys. [PDF]

Drug Alcohol Depend
Rough MI, Lewis EA, Rough CF, Nader MA.
europepmc   +1 more source

Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats. [PDF]

PLoS One
Rowan C, Hanna C, Sajjad M, Yao R, Sharafsha A, Lewandrowski KU, Blum K, Pinhasov A, Thanos PK.   +8 more
europepmc   +1 more source

Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity

Hesen R, Mottarlini F, Caffino L, Fennema S, Parolaro S, Guerrin CGJ, Quednow BB, Fumagalli F, Verheij MM, Homberg JR.   +9 more
europepmc   +1 more source

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Review of self-administration

Drug and Alcohol Dependence, 1985
The reinforcing properties of drugs can be evaluated pre-clinically using self-administration procedures in laboratory animals. This paper reviews self-administration studies of the four opioid agonist/antagonist analgesics pentazocine, butorphanol, nalbuphine and buprenorphine, and compares these results to those from studies of morphine and ...
R L, Balster, S E, Lukas
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Self-administration cues as signals: Drug self-administration and tolerance.

Journal of Experimental Psychology: Animal Behavior Processes, 2001
There is evidence that drug-associated exteroceptive cues elicit compensatory conditional responses (CCRs) that contribute to tolerance. The authors evaluated whether interoceptive, self-administration cues (SACs) similarly contribute to tolerance. In Experiments 1 and 2, the ataxic effect of ethanol was measured in rats that self-administered (SA ...
L, Weise-Kelly, S, Siegel
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Nicotine self-administration in rats

Psychopharmacology, 1995
Considering the importance of self-administration models in determining mechanisms of drug maintained behavior, we attempted to replicate the findings of nicotine self-administration by Corrigall and Coen. Male, Sprague-Dawley rats, trained on food reinforcement, acquired relatively high and stable rates of self-administration of IV nicotine bitartrate
Eric Donny, A R Caggiula
exaly   +3 more sources

Pharmacology of drug self-administration

Alcohol, 1990
Limited access to drugs provides a reliable model for their acute-reinforcing effects and a means by which to explore neuropharmacological mechanisms involved in these effects. In limited access situations intravenous self-administration rates of opiates and psychomotor stimulants is inversely related to dose, and competitive antagonists at low doses ...
G F, Koob, F, Weiss
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Methamphetamine self-administration by humans

Psychopharmacology, 2001
Methamphetamine abuse has become increasingly problematic. Yet, the reinforcing effects of methamphetamine in humans have not been systematically evaluated.To characterize methamphetamine's reinforcing effects in human research participants under controlled laboratory conditions.Eight healthy research volunteers (one female, seven males) completed this
C L, Hart, A S, Ward, M, Haney, R W, Foltin, M W, Fischman   +4 more
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