Results 41 to 50 of about 5,887,747 (305)
Natural Sciences, 2022 Crystallization of granular assemblies has broad implications for rapid and scalable creation of architected materials with applications ranging from structural materials to microarchitected battery electrodes.
Ivan Grega +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nanomaterials, 2018 In this study, a series of diblock glycopolymers, poly(6-O-methacryloyl-d-galactopyranose)-b-poly(6-cholesteryloxyhexyl methacrylate) (PMAgala-b-PMAChols), with cholesterol/galactose grafts were prepared through a sequential reversible addition ...
Zhao Wang +5 more
doaj +1 more source
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Nature Communications, 2022 Studying the specific roles of macrophage subsets has been hampered by a lack of subset-specific probes. Here the authors report an M1 selective fluorescent probe named CDr17, and demonstrate the suitability of this probe for tracking M1 macrophages in ...
Heewon Cho +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Self-assembling prodrugs [PDF]
Chem. Soc. Rev., 2017 Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. Self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies.
Andrew G. Cheetham +3 more
openaire +2 more sources
Chapter 11 Programmable Self-Assembly—Theoretical Aspects and DNA-Linked Nanoparticles
, 2008 We briefly present a method for the parameterization of assembly systems derived from their ability to form unique structures. The concept of bond uniqueness is introduced and we show how it influences the number of unique structures that a programmable,
J. Liu-Helmersson +9 more
core +1 more source
Shape-induced anisotropy in antidot arrays from self-assembled templates [PDF]
, 2005 Using self-assembly of polystyrene spheres, well-ordered templates have been prepared on glass and silicon substrates. Strong guiding of self-assembly is obtained on photolithographically structured silicon substrates.
P.A.J. de Groot +25 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Methacrylate-based amphiphilic block copolymers in solution and at surfaces : synthesis, characterization and self-assembly [PDF]
, 2008 Part 1. Introduction General concept of polymer self-assembly, synthesis of amphiphilic block copolymers and their application in biotechnology are briefly presented.
Rakhmatullina, Ekaterina
core +1 more source