Results 61 to 70 of about 526,899 (292)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Rational design of crystalline two-dimensional frameworks with highly complicated topological structures

Nature Communications, 2019
Constructing two-dimensional (2D) polymers with complex tessellation patterns is important for the fabrication of advanced materials but achieving such complexity is a great challenge.
Rong-Ran Liang, Shun-Qi Xu, Lei Zhang, Ru-Han A, Pohua Chen, Fu-Zhi Cui, Qiao-Yan Qi, Junliang Sun, Xin Zhao   +8 more
doaj   +1 more source

Verification in Staged Tile Self-Assembly

, 2017
We prove the unique assembly and unique shape verification problems, benchmark measures of self-assembly model power, are $\mathrm{coNP}^{\mathrm{NP}}$-hard and contained in $\mathrm{PSPACE}$ (and in $\mathrm{\Pi}^\mathrm{P}_{2s}$ for staged systems with
A Winslow, D Doty, ED Demaine, ED Demaine, ED Demaine, LJ Stockmeyer, M Schaefer, N Bryans, Q Cheng   +8 more
core   +1 more source

Self-assembly via microfluidics

Lab on a Chip, 2015
Microfluidic techniques provide an intriguing method to control kinetic aspects of the self-assembly of molecular amphiphiles by the facile adjustment of the hydrodynamics of the fluids.
Lei Wang, Samuel Sánchez
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Creating amphiphilic porosity in two-dimensional covalent organic frameworks via steric-hindrance-mediated precision hydrophilic-hydrophobic microphase separation

Nature Communications
Creating different pore environments within a covalent organic framework (COF) will lead to useful multicompartment structure and multiple functions, which however has been scarcely achieved.
Shu-Yan Jiang, Zhi-Bei Zhou, Shi-Xian Gan, Ya Lu, Chao Liu, Qiao-Yan Qi, Jin Yao, Xin Zhao   +7 more
doaj   +1 more source

Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells

Materials Today Bio, 2022
In vivo blood vessels imaging is crucial to study blood vessels related diseases in real-time. For this purpose, fluorescent based imaging is one of the utmost techniques for imaging a living system. The discovery of a new near-infrared probe (CyA-B2) by
Muhammad Asri Abdul Sisak, Fiona Louis, Tomoyuki Miyao, Sun Hyeok Lee, Young-Tae Chang, Michiya Matsusaki   +5 more
doaj   +1 more source

Negative Interactions in Irreversible Self-Assembly

, 2010
This paper explores the use of negative (i.e., repulsive) interaction the abstract Tile Assembly Model defined by Winfree. Winfree postulated negative interactions to be physically plausible in his Ph.D.
D. Doty, D. Soloveichik, G. Aggarwal, H. Wang, J.H. Reif, N.C. Seeman, R. Schoen   +6 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

DNA-guided self-assembly in living cells

iScience, 2023
Summary: Self-assembly processes exist widely in life systems and play essential roles in maintaining life activities. It is promising to explore the molecular fundamentals and mechanisms of life systems through artificially constructing self-assembly ...
Jinqiao Liu, Jianpu Tang, Zhaobin Tong, Guangshuai Teng, Dayong Yang   +4 more
doaj   +1 more source