Results 51 to 60 of about 18,428 (265)

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Seismic performance and resilience assessment of an innovative self-centering modular disc spring device

Results in Engineering
This paper presents a self-centering modular disc spring device (SC-MDSD) equipped with an adjustable modular partition that allows the length of the disc spring stack (SDS) to be modified to meet practical construction needs.
Yuan Liao, Shangwen Liu, Sizhi Zeng, Shujun Hu, Zhigang Yang, Jinzhou Bai   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Detour Distance And Self Centered Graphs

Journal of Mathematics and Computer Science, 2014
This paper evaluates the detour distance of a graph and associated problems. We study about the detour eccentricity and average detour eccentricity of graphs and derive some of the properties that relates self centered graphs and detour distance. A characterization of tree is also discussed.
K. R. S. Narayan, M.s. Sunitha
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Seismic Performance Evaluation of Reinforced Concrete Building Structure Retrofitted with Self-Centering Disc-Slit Damper and Conventional Steel Slit Damper

Buildings
To meet the recent requirements of low-damage design, there is a growing need to retrofit building structures with a self-centering dissipation system.
Asad Naeem, Kusunoki Koichi, Joohno Lee
doaj   +1 more source

Does the Self-Centering Mechanism of Bipolar Hip Endoprosthesis Really Work ?

Journal of Orthopaedic Surgery, 2005
Purposes. To examine radiographically the component motion in a bipolar prosthesis and to determine whether the self-centering mechanism really works in vivo . Methods.
H Tsumura, N Kaku, T Torisu
doaj   +1 more source