Results 61 to 70 of about 3,054,586 (305)
工程科学与技术, 2019 To investigate the anti-seismic resilience of inter-story substructure of PEC column-steel beam frame with partial self-centering friction damped connection, a specimen with 1∶2 scale was designed and fabricated, then two tests before and after ...
Youzhen FANG +3 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Advances in Civil Engineering, 2018 Austenitic shape memory alloy has potential applications in self-centering seismic resistant structural systems due to its superelastic response under cyclic tension.
Xian Xu, Guangming Cheng, Junhua Zheng
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Study of Failure Mode and Ultimate Bearing Capacity for Self-Centering SMA Connection
BuildingsAn innovative self-centering shape memory alloy (SMA) connection that is used in a steel frame beam-column joint was developed to improve the energy dissipative capacity and self-centering capacity, and reduce the residual deformation.
Xiaozhu Fu +3 more
doaj +1 more source
Detour Distance And Self Centered Graphs
Journal of Mathematics and Computer Science, 2014 This paper evaluates the detour distance of a graph and associated problems. We study about the detour eccentricity and average detour eccentricity of graphs and derive some of the properties that relates self centered graphs and detour distance. A characterization of tree is also discussed.
K. R. S. Narayan, M.s. Sunitha
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source