Results 81 to 90 of about 3,054,586 (305)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The relation of self-concept to desirable educational outcomes

, 2006
Reviewers (Byrne, 1996a, 1996b; Hattie, 1992; Marsh, Byrne, & Shavelson, 1988; Marsh & Craven, 1997; Craven, Marsh, & Burnett, 2003) consider that self-concept is multifaceted and espouse that self-concept cannot be adequately understood if its ...
Craven, Rhonda, Munns, Geoff, Ha, My Trinh, Martin, Andrew J.   +3 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Seismic performance and resilience assessment of an innovative self-centering modular disc spring device

Results in Engineering
This paper presents a self-centering modular disc spring device (SC-MDSD) equipped with an adjustable modular partition that allows the length of the disc spring stack (SDS) to be modified to meet practical construction needs.
Yuan Liao, Shangwen Liu, Sizhi Zeng, Shujun Hu, Zhigang Yang, Jinzhou Bai   +5 more
doaj   +1 more source

A comprehensive multilevel model meta-analysis of self-concept interventions

, 2006
The efficacy of self-concept interventions has previously been examined through traditional meta-analytic methods, and a host of moderators of intervention outcomes have been identified (O’Mara, Marsh, & Craven, 2004; Haney & Durlak, 1998; Hattie, 1992).
Craven, Rhonda, Marsh, Herbert W., O'Mara, Alison J.   +2 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Body image and self-concept in adolescent girls

, 2006
Anorexia Nervosa has been recently recognized as one of the most common chronic illnesses that affects the female adolescent population today. Although there has been an abundance of research into eating disorders in a variety of fields, significant ...
Halse, Christine, Ha, My Trinh, Marsh, Herbert W., Martin, Andrew J.   +3 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Seismic Performance Evaluation of Reinforced Concrete Building Structure Retrofitted with Self-Centering Disc-Slit Damper and Conventional Steel Slit Damper

Buildings
To meet the recent requirements of low-damage design, there is a growing need to retrofit building structures with a self-centering dissipation system.
Asad Naeem, Kusunoki Koichi, Joohno Lee
doaj   +1 more source

How Do Nurses Apply Personal Knowing to Patient Care? A Grounded Theory Study

Journal of Client-centered Nursing Care, 2021
Background: Personal Knowing (PK) is an expression of self-knowledge concerning others. Besides, PK is the most difficult as well as the most essential pattern of knowing in nursing.
Forough Rafii, Fereshteh Javaheri Tehrani, Alireza Nikbakht Nasrabadi, Shabnam Shariatpanahi   +3 more
doaj