Results 51 to 60 of about 3,054,586 (305)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Emerging superelastic SMA core damping elements for seismic application
Frontiers in Built Environment, 2023 Structural and non-structural damage reported after recent strong earthquakes promotes a fundamental shift in structural design target from “collapse resistance” to “fast structural function recovery”.
Cheng Fang, Michael CH Yam
doaj +1 more source
Residual drift analyses of realistic self-centering concrete wall systems
, 2016 To realise the full benefits of a self-centering seismic resilient system, the designer must ensure that the entire structure does indeed re-center following an earthquake.
Ingham, Jason +2 more
core +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Collapse Capacity Analysis of Self-centering Precast Shear Walls Based on IDA
工程科学与技术, 2018 Self-centering precast concrete shear walls were constructed by using post-tensioning strands to assemble prefabricated wall panels along vertical direction.
Hao WU +3 more
doaj
BuildingsIn order to enhance the self-centering capacity of steel frame structures after earthquakes and reduce the tubes of traditional double-tube or triple-tube SC-BRB, an innovative single-tube self-centering buckling restrained brace (ST-SC-BRB) is proposed ...
Yourong Lin +4 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Shock and Vibration, 2020 This paper presents an experimental study on the seismic performance of a bidirectional self-centering reinforced concrete (RC) frame structure. In the structure, the column-base joints, which were installed with external mild steel (MS) dampers, could ...
Zhenying Wang, Chenxi Mao, Lili Xie
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source