Results 71 to 80 of about 14,235 (263)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Analysis of Seismic Performance for Segmentally Assembled Double-Column Bridge Structures Based on Equivalent Stiffness

Buildings
Double-column self-centering segmentally assembled bridges (SC-SABs) present greater design complexity compared to single-column systems, primarily due to vertical stiffness discontinuities at segmental spandrel abutments, which critically affect the ...
Huixing Gao, Wenjing Xia, Guoqing Liu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Experimental Evaluation of Wedge-Type Anchorage Systems for Smooth-Surfaced NiTi SMA Bars

Buildings
SMA bars, particularly those based on NiTi, exhibit superelastic and self-centering properties, providing damage-resistant, self-centering structural systems.
Moustafa Basha, Anas Issa, Ahmed Bediwy
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Seismic Performance Research of Self-Centering Single-Column Bridges Using Equivalent Stiffness Theory

Buildings
Single-column hybrid-reinforced self-centering segmental assembled bridges (SHR-SCSAB) exhibit vertical stiffness discontinuities, significantly impacting the refinement of their seismic design methodology.
Huixing Gao, Wenjing Xia, Hongxu Lu
doaj   +1 more source

MATHEMATICAL MODEL OF WHEELSET OSCILLATIONS WITH INDEPENDENT WHEEL ROTATION IN THE HORIZONTAL PLANE

Nauka ta progres transportu, 2016
Purpose. The work is devoted to the study of horizontal oscillation and the assessment of the motion stability of a single wheelset with independent wheel rotation, and to the comparison of stability indicators of the typical wheelset and the wheelset ...
S. V. Myamlin, O. A. Kirilchuk, V. S. Metyzhenko   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Experimental and Numerical Investigation on Three-Segment Precast Bridge Columns with Grouted Sleeve-Unbonded Prestressing Hybrid Connections

Buildings
Precast bridge columns offer efficiency and environmental benefits, yet complex mountainous terrain and limited workspace severely restrict the transportation of large segments.
Bo Yi, Ningyu Zhao, Guozheng Chen, Haitao Tang, Boheng Zhang, Guan Wang   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source