Results 61 to 70 of about 14,235 (263)

Energy-based design procedure for self-centering shear wall systems

, 2023
Abstract Self-centering shear wall systems (SCSWSs) exhibit superior aseismic capacities with low-damage and self-centering features. However, the cumulative effect under long-period earthquakes would diminish robustness of the system and lead to increased unrecoverable damages. Thus, it should be considered in seismic designs for SCSWSs.
Ge Song, Lili Xing
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental Study on a Self-Centering Earthquake-Resistant Masonry Pier with a Structural Concrete Column

Advances in Materials Science and Engineering, 2017
This paper proposes a slotting construction strategy to avoid shear behavior of multistory masonry buildings. The aspect ratio of masonry piers increases via slotting between spandrels and piers, so that the limit state of piers under an earthquake may ...
Lijun Niu, Wenfang Zhang
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Seismic Performance of Concentrically Braced Steel Frames Equipped with Novel Self-Centering Dual-Stage Yielding Buckling-Restrained Braces

Buildings
Conventional buckling-restrained braces provide stable and efficient hysteretic energy dissipation but lack a recentering mechanism and adequate deformation capacity, which may result in significant residual deformations after strong earthquakes ...
Qianzhan Cheng, Yan Shi, Hongguo Qin, Yu Ding   +3 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Seismic performance assessment of self-centering dual systems with different configurations

Structures, 2016
Abstract Concentrically braced frame (CBF) systems have limited capacity for lateral displacement, causing structural damage that leads to high post-earthquake costs under moderate earthquakes. Self-centering concentrically braced frame (SC-CBF) systems have been developed to soften the lateral force–lateral drift response of the system without ...
Mehdei Kafaeikivi, David A. Roke, Qindan Huang   +2 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Seismic Performance Evaluation of a Frame System Strengthened with External Self-Centering Components

Buildings
In the context of China’s promotion of green buildings and resilient urban development, new reinforcement technologies offer significant development prospects, while traditional methods have limited effectiveness in enhancing structural resilience.
Yulin Fan, Jiaye Song, Xuelu Zhou, Hang Liu   +3 more
doaj   +1 more source