Results 41 to 50 of about 14,235 (263)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Collapse Capacity Analysis of Self-centering Precast Shear Walls Based on IDA

工程科学与技术, 2018
Self-centering precast concrete shear walls were constructed by using post-tensioning strands to assemble prefabricated wall panels along vertical direction.
Hao WU, Xilin LYU, Ying ZHOU, Wenguang LIU   +3 more
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A Comparative Study of the Seismic Performance of Self-Centering CRBFs and BRBF Systems

Iranian Journal of Science and Technology, Transactions of Civil Engineering
Abstract The current seismic design philosophy of building structures relies on the inelastic response of the main structural elements as the principal source for dissipating the seismic energy. The product of this philosophy is considerable levels of residual drifts that could make building structures look unsafe to their occupants.
Mostafa Ramadan, Hamdy Abou-Elfath, Mohab Turkomany   +2 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tri-axial Self-centering Reinforced Concrete Frame and Its Quasi-static Test

工程科学与技术, 2018
Self-centering reinforced concrete frame is a new type of earthquake resilient structure.Comparing to conventional RC structures,self-centering structure is known for its minimal damage under earthquakes and little residual deformation after earthquakes ...
Xilin LU, Chun JIANG, Xu LU
doaj  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Resilient self-centering viscous-based bracing with SMA and friction springs: Multi-objective control of displacement and acceleration – an analytical study

Resilient Cities and Structures
Self-Centering Piston-Based Braced Frames (SC-PBBFs) are designed to curtail structural damage under severe ground motions. The self-centering mechanism in this bracing mitigates structural damage during an earthquake, thereby reducing post-earthquake ...
Navid Rahgozar, M.Shahria Alam
doaj   +1 more source

A Simplified Model for Dynamic Response Analysis of Framed Self-Centering Wall Structures under Seismic Excitations

Shock and Vibration, 2019
This paper presents a simplified model for dynamic response analysis of the framed self-centering wall (FSCW) structure under seismic excitations. In the analysis model, the frame is equivalent as a single-degree-of-freedom system and collaborates with ...
Xiaobin Hu, Chen Lu, Xiaoqing Zhu
doaj   +1 more source